Molecular structure of Xanomeline oxalate, CAS Number: 141064-23-5
Xanomeline oxalate (CAS 141064-23-5)
Alternate Names:
3-[4-(Hexyloxy)-1,2,5-thiadiazol-3- yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate
Application:
Xanomeline oxalate is a functionally selective mAChR M1 agonist
CAS Number:
141064-23-5
Purity:
≥98%
Molecular Weight:
371.45
Molecular Formula:
C14H23N3OS•C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Xanomeline oxalate is a functionally selective mAChR M1 agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at mAChR M1, mAChR M3, mAChR M5, mAChR M4 and mAChR M2 receptors, respectively). It exhibits a reversible and wash-resistant binding resulting in full agonist activity at mAChR M1, delayed wash-resistant partial agonist activity at mAChR M2 and delayed wash-resistant full agonist activity at mAChR M4.
Xanomeline oxalate (CAS 141064-23-5) References
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- Importance and prospects for design of selective muscarinic agonists. | Jakubík, J., et al. 2008. Physiol Res. 57 Suppl 3: S39-S47. PMID: 18481916
- Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. | Heinrich, JN., et al. 2009. Eur J Pharmacol. 605: 53-6. PMID: 19168056
- Predictive validity of a MK-801-induced cognitive impairment model in mice: implications on the potential limitations and challenges of modeling cognitive impairment associated with schizophrenia preclinically. | Brown, JW., et al. 2014. Prog Neuropsychopharmacol Biol Psychiatry. 49: 53-62. PMID: 24269664
- Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. | Odagaki, Y., et al. 2016. J Psychopharmacol. 30: 896-912. PMID: 27464743
- A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockade by Oxotremorine-M. | Zwart, R., et al. 2016. Eur J Pharmacol. 791: 221-228. PMID: 27590358
- STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit. | Tian, M., et al. 2016. Sci Rep. 6: 36684. PMID: 27857196
- Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. | Zwart, R., et al. 2018. Biochem Biophys Res Commun. 495: 481-486. PMID: 29127015
- TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys. | Kurimoto, E., et al. 2019. PLoS One. 14: e0207969. PMID: 30856192
- Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons. | Kreir, M., et al. 2019. Eur J Pharmacol. 858: 172474. PMID: 31238068
- In Vivo Pharmacological Comparison of TAK-071, a Positive Allosteric Modulator of Muscarinic M1 Receptor, and Xanomeline, an Agonist of Muscarinic M1/M4 Receptor, in Rodents. | Mandai, T., et al. 2019. Neuroscience. 414: 60-76. PMID: 31299348
- Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor. | McDonald, JK., et al. 2022. ACS Chem Neurosci. 13: 1206-1218. PMID: 35380782
- Click Chemistry-Enabled Conjugation Strategy for Producing Dibenzodiazepinone-Type Fluorescent Probes To Target M2 Acetylcholine Receptors. | Yang, H., et al. 2022. Bioconjug Chem. 33: 2223-2233. PMID: 36327428
Activator of:
mAChR M1, and mAChR M3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xanomeline oxalate, 10 mg | sc-204402 | 10 mg | $155.00 |