Xamoterol hemifumarate (CAS 73210-73-8)
QUICK LINKS
Xamoterol hemifumarate is a compound used in the research of cardiovascular functions, particularly as a selective beta-1 adrenergic receptor agonist. Its hemifumarate salt form enhances its solubility for experimental use. In research applications, xamoterol hemifumarate is employed to study the regulation of heart rate, myocardial contractility, and cardiac output, as these are influenced by beta-1 adrenergic receptor activity. It serves as a tool for understanding the beta-adrenergic signaling pathways and the physiological responses following receptor activation. Furthermore, it is used to investigate the potential compensatory mechanisms in heart failure models, where beta-1 receptor sensitivity may be altered. Xamoterol hemifumarate is also of interest in the study of chronotropic and inotropic effects in cardiac tissues and their implications for cardiac performance under various conditions.
Xamoterol hemifumarate (CAS 73210-73-8) References
- Beta2-adrenergic receptor antagonist accelerates skin barrier recovery and reduces epidermal hyperplasia induced by barrier disruption. | Denda, M., et al. 2003. J Invest Dermatol. 121: 142-8. PMID: 12839574
- Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala. | Roozendaal, B., et al. 2004. J Neurosci. 24: 8161-9. PMID: 15371517
- A requirement for memory retrieval during and after long-term extinction learning. | Ouyang, M. and Thomas, SA. 2005. Proc Natl Acad Sci U S A. 102: 9347-52. PMID: 15947076
- Beta1-adrenergic receptors maintain fetal heart rate and survival. | Chandra, R., et al. 2006. Biol Neonate. 89: 147-58. PMID: 16210849
- beta1- and beta2-adrenoceptor induced synaptic facilitation in rat basolateral amygdala. | Abraham, PA., et al. 2008. Brain Res. 1209: 65-73. PMID: 18396264
- The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. | Barbatelli, G., et al. 2010. Am J Physiol Endocrinol Metab. 298: E1244-53. PMID: 20354155
- Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. | Faizi, M., et al. 2011. Neurobiol Dis. 43: 397-413. PMID: 21527343
- Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling. | Schutsky, K., et al. 2011. Learn Mem. 18: 598-604. PMID: 21878527
- Ca(2+)-dependent large conductance K(+) currents in thalamocortical relay neurons of different rat strains. | Ehling, P., et al. 2013. Pflugers Arch. 465: 469-80. PMID: 23207578
- Excitatory effect of norepinephrine on neurons in the inferior vestibular nucleus and the underlying receptor mechanism. | Peng, SY., et al. 2016. J Neurosci Res. 94: 736-48. PMID: 27121461
- The in vitro pharmacology of xamoterol (ICI 118,587). | Malta, E., et al. 1985. Br J Pharmacol. 85: 179-87. PMID: 2862938
- Rationale and design of an inhibitor of RecA protein as an inhibitor of Acinetobacter baumannii. | Tiwari, V., et al. 2018. J Antibiot (Tokyo). 71: 522-534. PMID: 29410519
- Measurement of xamoterol in plasma and urine by high-performance liquid chromatography. | Oddie, CJ., et al. 1984. J Chromatogr. 308: 370-5. PMID: 6146637
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xamoterol hemifumarate, 10 mg | sc-361406 | 10 mg | $171.00 | |||
Xamoterol hemifumarate, 50 mg | sc-361406A | 50 mg | $473.00 |