Xaliproden hydrochloride CAS: 90494-79-4
MF: C24N22F3N•HCl
MW: 417.89
A full agonist of SR-1A.

Xaliproden hydrochloride (CAS 90494-79-4)

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Alternate Names: SR 57746A
Application: Xaliproden hydrochloride is a full agonist of SR-1A
CAS Number: 90494-79-4
Purity: ≥99%
Molecular Weight: 417.89
Molecular Formula: C24N22F3N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Xaliproden hydrochloride is a full agonist at SR-1A receptors. Xaliproden hydrochloride increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. It displays neurotrophic activity in several neurodegenerative models in vitro. Xaliproden hydrochloride binds rat SR-1A with high affinity (ki - 2.0 nM) and is > 300-fold selective over other serotonin receptor subtypes (IC50 > 650 nM).


References

1. Bachy, A., et al. 1993. Fund. Clin. Pharmacol. 7: 487-497.
2. Fournier, J., et al. 1993. Neuroscience. 55: 629-641.
3. Duong, F.H., et al. 1999. Br. J. Pharmacol. 128: 1385-1392.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (20 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.59 (Predicted)
Ki Data :
5-HT1A receptors: Ki= 2 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UT8405666
PubChem CID :
Merck Index :
14: 10054
MDL Number :
MFCD00896209
SMILES :
C1CN(CC=C1C2=CC(=CC=C2)C(F)(F)F)CCC3=CC4=CC=CC=C4C=C3.Cl

Download SDS (MSDS)

Certificate of Analysis

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