Molecular structure of Xaliproden hydrochloride, CAS Number: 90494-79-4
Xaliproden hydrochloride (CAS 90494-79-4)
Alternate Names:
SR 57746A
Application:
Xaliproden hydrochloride is a full agonist of SR-1A
CAS Number:
90494-79-4
Purity:
≥96.0%
Molecular Weight:
417.89
Molecular Formula:
C24N22F3N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Xaliproden hydrochloride is a full agonist at SR-1A receptors. Xaliproden hydrochloride increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. It displays neurotrophic activity in several neurodegenerative models in vitro. Xaliproden hydrochloride binds rat SR-1A with high affinity (ki - 2.0 nM) and is > 300-fold selective over other serotonin receptor subtypes (IC50 > 650 nM).
Xaliproden hydrochloride (CAS 90494-79-4) References
- Quantification of neurotrophin mRNA expression in PMN mouse: modulation by xaliproden. | Appert-Collin, A., et al. 2004. Int J Immunopathol Pharmacol. 17: 157-64. PMID: 15171816
- MAPK activation via 5-hydroxytryptamine 1A receptor is involved in the neuroprotective effects of xaliproden. | Appert-Collin, A., et al. 2005. Int J Immunopathol Pharmacol. 18: 21-31. PMID: 15698508
- Xaliproden (SR57746A) induces 5-HT1A receptor-mediated MAP kinase activation in PC12 cells. | Appert-Collin, A., et al. 2005. Int J Immunopathol Pharmacol. 18: 233-44. PMID: 15888246
- Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. | Chang, CW., et al. 2009. Neuropharmacology. 56 Suppl 1: 213-25. PMID: 18762202
- 5-HT1A receptors are involved in the effects of xaliproden on G-protein activation, neurotransmitter release and nociception. | Martel, JC., et al. 2009. Br J Pharmacol. 158: 232-42. PMID: 19508400
- Agonists at the serotonin receptor (5-HT(1A)) protect the retina from severe photo-oxidative stress. | Collier, RJ., et al. 2011. Invest Ophthalmol Vis Sci. 52: 2118-26. PMID: 21087971
- Literature review and practical aspects on the management of oxaliplatin-associated toxicity. | Hoff, PM., et al. 2012. Clin Colorectal Cancer. 11: 93-100. PMID: 22154408
- Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart. | Boerma, M., et al. 2013. PLoS One. 8: e70479. PMID: 23936211
- Current strategies to minimize toxicity of oxaliplatin: selection of pharmacogenomic panel tests. | Di Francia, R., et al. 2013. Anticancer Drugs. 24: 1069-78. PMID: 24025562
- Effects of xaliproden, a 5-HT₁A agonist, on mechanical allodynia caused by chemotherapeutic agents in mice. | Andoh, T., et al. 2013. Eur J Pharmacol. 721: 231-6. PMID: 24070812
- 5-HT1A receptor agonists, xaliproden and tandospirone, inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice. | Andoh, T., et al. 2016. J Pharmacol Sci. 131: 284-7. PMID: 27562704
Activator of:
Serotonin, and SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xaliproden hydrochloride, 10 mg | sc-203721 | 10 mg | $224.00 | |||
Xaliproden hydrochloride, 50 mg | sc-203721A | 50 mg | $898.00 |