X11α Antibody (23): sc-136122
- X11α Antibody (23) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against amino acids 268-377 of X11α of rat origin
- recommended for detection of X11α of mouse and rat origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for X11α Antibody (23). This work is in progress.
X11α Antibody (23) is a mouse monoclonal IgG1 antibody that detects X11α in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). X11α is a neuronal transmembrane protein that plays a crucial role in modulating the processing of the β-Amyloid precursor protein (β-APP), which is a significant factor in the development of Alzheimer′s disease. By binding to the YENPTY motif of β-APP via its phosphotyrosine binding (PTB) domain, X11α reduces the secretion of cellular β-APP and slows down its processing pathways, thereby influencing amyloid plaque formation. The interaction between X11α and β-APP is vital for understanding the mechanisms underlying Alzheimer′s pathology, as X11α highlights potential therapeutic targets for intervention. Additionally, multiple splice variants of X11, including X11α (Mint 1), X11β (Mint 2), and X11γ (Mint 3), have been identified, each contributing to the complexity of β-APP regulation and its implications in neurodegenerative diseases. Anti-X11α antibody (23) is an essential tool for researchers investigating the intricate relationships between β-APP processing and Alzheimer′s disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
X11α Antibody (23) | sc-136122 | 50 µg/0.5 ml | $322.00 |