WT1 Antibody (H-1): sc-393498

WT1 Antibody (H-1) is a mouse monoclonal IgM kappa light chain antibody targeting an epitope between amino acids 123-164 within the internal region of the human-origin Wilms′ Tumor 1 protein (WT1), also known as WT33 or EGR-2. Anti-WT1 antibody (H-1) reacts with mouse, rat, and human species and is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). WT1 is a zinc finger transcription factor that plays a crucial role in kidney and gonadal development by regulating genes involved in cell growth, differentiation, and apoptosis. Predominantly localized in the nucleus, WT1′s cellular location is essential for its function as a transcriptional regulator, and any mislocalization can disrupt gene expression patterns. Mutations or altered expression of WT1 are associated with Wilms′ tumor, a pediatric kidney cancer, as well as other malignancies like leukemia and mesothelioma. Understanding WT1′s nuclear localization and function is important for deciphering the molecular mechanisms of tumorigenesis and normal organ development. WT1 monoclonal antibody (H-1) can effectively detect the expression and intracellular distribution of WT1, providing insights into its role in health and disease. Anti-WT1 antibody (H-1) serves as a valuable tool for advancing research in developmental biology and oncology, potentially aiding in the development of targeted therapies.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WT1 Antibody (H-1) has 23 citations in a variety of scientific publications.

Primary antibodies like Anti-WT1 Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WT1 Antibody (H-1) Specifications

Alternate Product Name: WT1

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 123-164

Epitope Target: WT1

Epitope Species: human

Product Reactivity/Detection: WT1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for WT1 Antibody (H-1): P: Blocking Peptide

The preferred WT1 antibody is WT1 Antibody (F-6): sc-7385.