WS 12 (CAS 68489-09-8)
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WS 12 is a synthetic compound that is primarily used in research to understand the activation and modulation of transient receptor potential (TRP) channels, specifically TRPM8. It serves as useful for probing the structure-function relationships within these ion channels. The high potency and selectivity of WS 12 for TRPM8 make it particularly useful for in vitro studies aimed at delineating the pathways and mechanisms underlying the channel′s activation. Studies involving WS 12 are for elucidating the role of TRP channels in cellular signaling and in the response to environmental stimuli. Additionally, this compound is utilized in the development and characterization of assays that can be used to screen for modulators of TRPM8, which has broader implications in the field of molecular pharmacology and the study of sensation.
WS 12 (CAS 68489-09-8) References
- Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. | Behrendt, HJ., et al. 2004. Br J Pharmacol. 141: 737-45. PMID: 14757700
- Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. | Beck, B., et al. 2007. Cell Calcium. 41: 285-94. PMID: 16949669
- Characterisation of TRPM8 as a pharmacophore receptor. | Bödding, M., et al. 2007. Cell Calcium. 42: 618-28. PMID: 17517434
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- Practicability and sensitivity to change of the activities-specific balance confidence scale and 12-item Walking Scale for stroke. | Nilsagård, YE. and Forsberg, A. 2012. Top Stroke Rehabil. 19: 13-22. PMID: 22306624
- TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. | Liu, B., et al. 2013. Pain. 154: 2169-2177. PMID: 23820004
- Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts. | Tsumura, M., et al. 2013. PLoS One. 8: e82233. PMID: 24358160
- Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. | Yin, Y., et al. 2019. Science. 363: PMID: 30733385
- High-dose phenylephrine increases meningeal blood flow through TRPV1 receptor activation and release of calcitonin gene-related peptide. | Dux, M., et al. 2020. Eur J Pain. 24: 383-397. PMID: 31661581
- TRPM8 channel augments T-cell activation and proliferation. | Acharya, TK., et al. 2021. Cell Biol Int. 45: 198-210. PMID: 33090595
- Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro. | Suzuki, N., et al. 2020. Mol Nutr Food Res. e2000853. PMID: 33188562
- Irritant-evoked reflex tachyarrhythmia in spontaneously hypertensive rats is reduced by inhalation of TRPM8 agonists l-menthol and WS-12. | Hooper, JS. and Taylor-Clark, TE. 2023. J Appl Physiol (1985). 134: 307-315. PMID: 36603045
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WS 12, 5 mg | sc-204400B | 5 mg | $100.00 | |||
WS 12, 10 mg | sc-204400 | 10 mg | $145.00 | |||
WS 12, 50 mg | sc-204400A | 50 mg | $416.00 | |||
WS 12, 500 mg | sc-204400C | 500 mg | $4068.00 | |||
WS 12, 1 g | sc-204400D | 1 g | $8021.00 | |||
WS 12, 5 g | sc-204400E | 5 g | $16657.00 |