WR19L Cell Lysate: sc-3805

WR19L Cell Lysate is derived from WR19L cells, a murine lymphoma cell line extensively used in immunological and oncological research. This lysate contains a complex mixture of proteins, nucleic acids, and other cellular components, reflecting the biochemical environment of lymphoma cells. WR19L cells are known for their use in studying the mechanisms of lymphocyte signaling, particularly focusing on the activation and regulation of the NF-κB pathway, which is critical in immune response and cell survival. Researchers utilize WR19L Cell Lysate to analyze the expression and modification of key signaling molecules, including various kinases and transcription factors, through techniques such as western blotting, immunoprecipitation, and mass spectrometry. The lysate is also valuable in exploring the interactions between tumor cells and the immune system, helping to explain how lymphoma cells evade immune surveillance. Additionally, it serves as a model to test the effects of chemical activators and inhibitors on signaling pathways, providing insights into the molecular underpinnings of lymphoma progression and immune regulation. By employing WR19L Cell Lysate, scientists can further understand the dynamic processes involved in lymphocyte function and lymphoma biology, advancing research in cellular signaling and cancer mechanisms.

WR19L Cell Lysate References:

1. Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia.  |  Kojima, K., et al. 2007. Cancer Res. 67: 8121-30. PMID: 17804724