Molecular structure of WP631 dimethanesulfonate
WP631 dimethanesulfonate
See product citations (1)
Application:
WP631 dimethanesulfonate is a fluorescent bisintercalating anthracycline antibiotic with ultratight DNA binding
Purity:
≥95%
Molecular Weight:
1349.38
Molecular Formula:
C62H64N2O20•C2H8S2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
WP631 dimethanesulfonate is a preparation of the bisintercalating anthracycline antibiotic WP631, which is also available as a dihydrochloride (sc-222418) and a methanesulfonate (sc-301978) preparation. WP631 is composed of two Daunorubicin (sc-200921) molecules linked through a p-xylenyl group. WP631 is described to inhibit basal transcription by RNA polymerase II and to block the activation of COL1A1 by the transcription factor Sp1. WP631 is described to demonstrate ultratight binding of DNA and also appears to overcome a specific form of multidrug resistance in its action.
WP631 dimethanesulfonate References
- Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro. | Martín, B., et al. 1999. Nucleic Acids Res. 27: 3402-9. PMID: 10446226
- Analysis of the effects of daunorubicin and WP631 on transcription. | Portugal, J., et al. 2001. Curr Med Chem. 8: 1-8. PMID: 11172687
- Inhibition of basal and transforming growth factor-beta-induced stimulation of COL1A1 transcription by the DNA intercalators, mitoxantrone and WP631, in cultured human dermal fibroblasts. | Gaidarova, S. and Jiménez, SA. 2002. J Biol Chem. 277: 38737-45. PMID: 12138160
- Sequence selective binding of bis-daunorubicin WP631 to DNA. | Fox, KR., et al. 2004. Eur J Biochem. 271: 3556-66. PMID: 15317591
- Mineralocorticoid receptor interaction with SP1 generates a new response element for pathophysiologically relevant gene expression. | Meinel, S., et al. 2013. Nucleic Acids Res. 41: 8045-60. PMID: 23821666
- Structure-based design of a new bisintercalating anthracycline antibiotic. | Chaires, JB., et al. 1997. J Med Chem. 40: 261-6. PMID: 9022792
- Structure of a DNA-bisdaunomycin complex. | Hu, GG., et al. 1997. Biochemistry. 36: 5940-6. PMID: 9166763
- Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy. | Robinson, H., et al. 1997. Biochemistry. 36: 8663-70. PMID: 9289011
- Ultratight DNA binding of a new bisintercalating anthracycline antibiotic. | Leng, F., et al. 1998. Biochemistry. 37: 1743-53. PMID: 9485299
- Drug--DNA interactions. | Chaires, JB. 1998. Curr Opin Struct Biol. 8: 314-20. PMID: 9666327
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WP631 dimethanesulfonate, 500 µg | sc-222419 | 500 µg | $169.00 |