Wogonin (CAS 632-85-9)

Wogonin, a flavonoid compound derived from the root of Scutellaria baicalensis, has been extensively studied for its diverse research applications. One of its notable mechanisms of action lies in its ability to modulate various signaling pathways implicated in cellular processes. Research indicates that wogonin exerts its biological effects through the inhibition of key enzymes and transcription factors involved in inflammation, oxidative stress, and cancer progression. Specifically, wogonin has been shown to inhibit the activation of nuclear factor-kappa B (NF-κB) signaling, a central regulator of inflammatory responses, by blocking its nuclear translocation and DNA binding activity. Additionally, wogonin has demonstrated potent antioxidant activity by scavenging reactive oxygen species (ROS) and restoring cellular redox balance. Furthermore, wogonin has emerged as a promising candidate for cancer research due to its ability to induce apoptosis, inhibit cell proliferation, and suppress metastasis in various cancer cell lines and animal models. Beyond its anti-inflammatory and anticancer properties, wogonin has also been investigated for its neuroprotective, cardioprotective, and hepatoprotective effects, highlighting its utility in diverse pathological conditions. Ongoing research continues to unravel the molecular mechanisms underlying the pharmacological actions of wogonin, paving the way for its development as a novel agent and research tool in various scientific disciplines.