Wnt-11 Antibody (C-8): sc-365032

Wnt-11 Antibody (C-8) is a mouse monoclonal IgM antibody that detects Wnt-11 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Wnt-11 antibody (C-8) is available as the non-conjugated form. Wnt-11 plays a crucial role in developmental processes, particularly in regulating cell movements during gastrulation, which is essential for proper embryonic development. Wnt-11 is expressed in specific locations such as the tips of ureteric buds and the perichondrium, a layer of stem cell-like cells that surrounds future bones, guiding their growth and regeneration. Precise expression of Wnt-11 in these areas highlights its importance in orchestrating complex interactions necessary for organogenesis and tissue patterning. Wnt-11 is involved in signaling pathways that influence cell fate and behavior, making Wnt-11 a significant player in both normal development and potential pathological conditions. The gene encoding Wnt-11 is located on human chromosome 11q13.5, and Wnt-11 expression is tightly regulated, underscoring its importance in developmental biology and potential implications in cancer research.

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Wnt-11 Antibody (C-8) References:

1. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation.  |  Heisenberg, CP., et al. 2000. Nature. 405: 76-81. PMID: 10811221
2. Progressive induction of caudal neural character by graded Wnt signaling.  |  Nordström, U., et al. 2002. Nat Neurosci. 5: 525-32. PMID: 12006981
3. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis.  |  Pandur, P., et al. 2002. Nature. 418: 636-41. PMID: 12167861
4. Distinct roles for Wnt-4 and Wnt-11 during retinoic acid-induced neuronal differentiation.  |  Elizalde, C., et al. 2011. Stem Cells. 29: 141-53. PMID: 21280163
5. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.  |  Gavin, BJ., et al. 1990. Genes Dev. 4: 2319-32. PMID: 2279700
6. Wnt-11 overexpression promoting the invasion of cervical cancer cells.  |  Wei, H., et al. 2016. Tumour Biol. 37: 11789-11798. PMID: 27034261
7. The interaction of Wnt-11 and signalling cascades in prostate cancer.  |  Koushyar, S., et al. 2016. Tumour Biol. 37: 13049-13057. PMID: 27514543
8. Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.  |  Murillo-Garzón, V., et al. 2018. Nat Commun. 9: 1747. PMID: 29717114
9. Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer.  |  Gorroño-Etxebarria, I., et al. 2019. Cancers (Basel). 11: PMID: 31261741
10. Wnt-11 Expression Promotes Invasiveness and Correlates with Survival in Human Pancreatic Ductal Adeno Carcinoma.  |  Dart, DA., et al. 2019. Genes (Basel). 10: PMID: 31718047
11. Assignment of early caudal identity to neural plate cells by a signal from caudal paraxial mesoderm.  |  Muhr, J., et al. 1997. Neuron. 19: 487-502. PMID: 9331343
12. Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung.  |  Lako, M., et al. 1998. Gene. 219: 101-10. PMID: 9757009

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Wnt-11 Antibody (C-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Wnt-11 Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Wnt-11 Antibody (C-8) Specifications

Alternate Product Name: WNT11

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 116-210

Epitope Target: Wnt-11

Epitope Species: human

Product Reactivity/Detection: precursor and mature Wnt-11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Wnt-11 Antibody (C-8): N/A