Date published: 2026-5-1

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Withanoside V (CAS 256520-90-8)

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CAS Number:
256520-90-8
Molecular Weight:
766.91
Molecular Formula:
C40H62O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Withanoside V is a naturally occurring steroidal lactone glycoside extracted from the roots of Withania somnifera, commonly known as Ashwagandha. This compound is part of a group of phytochemicals known as withanolides, which are studied for their complex interactions with biological systems, focusing on their role in modulating signaling pathways and gene expression. In research settings, Withanoside V has been utilized to explore its impact on cellular mechanisms, particularly how it influences the activity of various signaling molecules and transcription factors. The compound has been shown to engage with specific receptor sites, leading to downstream effects that can alter cellular behavior, a feature that is of high interest in the study of plant-derived bioactives. Studies often employ techniques such as chromatography for purification and mass spectrometry for structural analysis, alongside molecular biology methods to assess its effects at the genetic level. Moreover, Withanoside V has been used in agricultural research to investigate its potential in enhancing stress tolerance in plants. This involves examining its role in the activation of defensive pathways that enable plants to better cope with environmental stressors. Thus, Withanoside V serves as a focal point in understanding the adaptive mechanisms of plants and their potential applications in improving crop resilience.


Withanoside V (CAS 256520-90-8) References

  1. Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin.  |  Dubey, S., et al. 2018. PLoS One. 13: e0200053. PMID: 30403672
  2. Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor.  |  Tripathi, MK., et al. 2021. J Biomol Struct Dyn. 39: 5668-5681. PMID: 32643552
  3. Investigating 11 Withanosides and Withanolides by UHPLC-PDA and Mass Fragmentation Studies from Ashwagandha (Withania somnifera).  |  Girme, A., et al. 2020. ACS Omega. 5: 27933-27943. PMID: 33163776
  4. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives.  |  Dubey, S., et al. 2021. Int J Biol Macromol. 173: 56-65. PMID: 33465364
  5. COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.  |  Kalra, RS., et al. 2022. J Biomol Struct Dyn. 40: 7885-7898. PMID: 33797339
  6. Phytometabolite profiling of Coronil, a herbal medicine for COVID-19, its identification by mass-spectroscopy and quality validation on liquid chromatographic platforms.  |  Balkrishna, A., et al. 2021. J Sep Sci. 44: 4064-4081. PMID: 34510772
  7. Early selective strategies for higher yielding bio-economic Indian ginseng based on genotypic study through metabolic and molecular markers.  |  Chauhan, S., et al. 2022. Saudi J Biol Sci. 29: 3051-3061. PMID: 35531148
  8. Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy.  |  Singh, M., et al. 2022. Front Cell Infect Microbiol. 12: 933824. PMID: 36046742
  9. The Efficacy of Traditional Medicinal Plants in Modulating the Main Protease of SARS-CoV-2 and Cytokine Storm.  |  Choe, J., et al. 2022. Chem Biodivers. 19: e202200655. PMID: 36125969
  10. In silico analysis and molecular docking studies of natural compounds of Withania somnifera against bovine NLRP9.  |  Ali, A., et al. 2023. J Mol Model. 29: 171. PMID: 37155030

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Withanoside V, 10 mg

sc-491961
10 mg
$700.00