Molecular structure of WEB-2086, CAS Number: 105219-56-5
WEB-2086 (CAS 105219-56-5)
See product citations (13)
Alternate Names:
Apafant; WEB 2086BS
Application:
WEB-2086 is a PAF-R antagonist shown to have anticancer effects
CAS Number:
105219-56-5
Purity:
≥98%
Molecular Weight:
455.96
Molecular Formula:
C22H22ClN5O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
WEB-2086 (Apafant) is a platelet activating factor receptor (PAF-R) antagonist shown to have anticancer and cell differentiation effects. It has been found to be a specific PAF-R antagonist in pulmonary vasculature and when administered intratracheally in rats. WEB-2086 was observed to decrease lung nuclear factor-kappaB (NF-kappaB) activation, myeloperoxidase activity, and lavage neutrophil numbers. It may act to be a cytodifferentiating agent in murine erythroleukemia cells in vitro. WEB-2086 inhibited cell growth and hemoglobin accumulation and also contains antiproliferative properties.
WEB-2086 (CAS 105219-56-5) References
- Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086. | Subbanagounder, G., et al. 1999. Circ Res. 85: 311-8. PMID: 10455059
- Effect of WEB 2086 on leukocyte adherence in response to hemorrhagic shock in rats. | Childs, EW., et al. 2000. J Trauma. 49: 1102-7. PMID: 11130496
- Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells. | Cellai, C., et al. 2002. FASEB J. 16: 733-5. PMID: 11923217
- Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. | Lee, YM., et al. 2002. J Lab Clin Med. 140: 312-9. PMID: 12434132
- Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. | Baltás, E., et al. 2003. Skin Pharmacol Appl Skin Physiol. 16: 259-62. PMID: 12784066
- WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential. | Laurenzana, A., et al. 2005. Leukemia. 19: 390-5. PMID: 15674364
- Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | Cellai, C., et al. 2006. Br J Cancer. 94: 1637-42. PMID: 16721373
- WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph. | Machado, EM., et al. 2006. J Insect Physiol. 52: 685-92. PMID: 16777137
- Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity. | Mann, O., et al. 2009. Pancreas. 38: 58-64. PMID: 18695628
- Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats. | Fuchs, H., et al. 2014. Drug Metab Dispos. 42: 1761-5. PMID: 25053619
- An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke. | Shukla, SD., et al. 2016. Int J Chron Obstruct Pulmon Dis. 11: 1647-55. PMID: 27524890
- Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. | Watanabe, M., et al. 2016. Am J Vet Res. 77: 969-75. PMID: 27580108
- Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist. | Casals-Stenzel, J., et al. 1987. Br J Pharmacol. 91: 799-802. PMID: 3664079
- A comparison of the actions of platelet activating factor (PAF) antagonists WEB 2170 and WEB 2086 in the horse. | Foster, AP., et al. 1993. J Vet Pharmacol Ther. 16: 477-87. PMID: 8126765
- The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. | Bastos da Silva, MB., et al. 1997. Vet Res Commun. 21: 521-31. PMID: 9345719
Inhibitor of:
2610005M20Rik, Angiogenesis, FPR2, PAF Acetylhydrolase, PAF-R, and PAFAH1B2.Activator of:
PAF-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WEB-2086, 1 mg | sc-201007 | 1 mg | $100.00 | |||
WEB-2086, 5 mg | sc-201007A | 5 mg | $163.00 |