WDR74 Antibody (E-6): sc-393822
- WDR74 Antibody (E-6) is a mouse monoclonal IgG1 WDR74 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 155-188 within an internal region of WDR74 of human origin
- WDR74 Antibody (E-6) is recommended for detection of WDR74 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- Anti-WDR74 Antibody (E-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WDR74 Antibody (E-6). This work is in progress.
WDR74 Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects WDR74 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WDR74 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WDR74 protein, also known as NOP seven-associated protein 1 (NSA1), is a 385 amino acid protein that plays a crucial role in the nucleolus, where WDR74 is involved in ribosome biogenesis and gene expression regulation. The presence of six WD repeats in WDR74′s structure allows participation in essential cellular processes, including chromatin assembly and signal transduction, which are vital for maintaining cellular homeostasis and responding to environmental cues. The gene encoding WDR74 is located on human chromosome 11, a region associated with several genetic disorders, including Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, and Niemann-Pick disease, highlighting WDR74′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WDR74 Antibody (E-6) References:
- The WD repeat: a common architecture for diverse functions. | Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
- WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. | Li, D. and Roberts, R. 2001. Cell Mol Life Sci. 58: 2085-97. PMID: 11814058
- The WD-40 repeat. | van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
- The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease. | Schuchman, EH. 2007. J Inherit Metab Dis. 30: 654-63. PMID: 17632693
- Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome). | Coldren, CD., et al. 2009. Neurogenetics. 10: 89-95. PMID: 18855024
- An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome. | Bhuiyan, ZA., et al. 2008. Prog Biophys Mol Biol. 98: 319-27. PMID: 19027783
- The ancient regulatory-protein family of WD-repeat proteins. | Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
- Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit. | Garcia-Higuera, I., et al. 1996. Biochemistry. 35: 13985-94. PMID: 8909296
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WDR74 Antibody (E-6) | sc-393822 | 200 µg/ml | $322.00 | |||
WDR74 Antibody (E-6) AC | sc-393822 AC | 500 µg/ml, 25% agarose | $424.00 | |||
WDR74 Antibody (E-6) HRP | sc-393822 HRP | 200 µg/ml | $322.00 | |||
WDR74 Antibody (E-6) FITC | sc-393822 FITC | 200 µg/ml | $336.00 | |||
WDR74 Antibody (E-6) PE | sc-393822 PE | 200 µg/ml | $349.00 | |||
WDR74 Antibody (E-6) Alexa Fluor® 488 | sc-393822 AF488 | 200 µg/ml | $364.00 | |||
WDR74 Antibody (E-6) Alexa Fluor® 546 | sc-393822 AF546 | 200 µg/ml | $364.00 | |||
WDR74 Antibody (E-6) Alexa Fluor® 594 | sc-393822 AF594 | 200 µg/ml | $364.00 | |||
WDR74 Antibody (E-6) Alexa Fluor® 647 | sc-393822 AF647 | 200 µg/ml | $364.00 | |||
WDR74 Antibody (E-6) Alexa Fluor® 680 | sc-393822 AF680 | 200 µg/ml | $364.00 | |||
WDR74 Antibody (E-6) Alexa Fluor® 790 | sc-393822 AF790 | 200 µg/ml | $364.00 | |||
WDR74 (E-6) Neutralizing Peptide | sc-393822 P | 100 µg/0.5 ml | $69.00 |