WDR4 Antibody (321.9): sc-100894
- WDR4 Antibody (321.9) is a mouse monoclonal IgG1 κ WDR4 antibody, cited in 3 publications, provided at 100 µg/ml
- raised against recombinant WDR4 of human origin
- recommended for detection of WDR4 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WDR4 Antibody (321.9). This work is in progress.
WDR4 Antibody (321.9) is a mouse monoclonal IgG1 kappa light chain antibody that detects WDR4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-WDR4 antibody (321.9) is available as a non-conjugated format. WDR4, also known as TRM82, is a 412 amino acid protein characterized by the presence of two WD-repeats, which are structural motifs that typically form a propeller-like tertiary structure. This unique structure facilitates WDR4′s role in various cellular processes, including chromatin assembly, cell cycle regulation, and RNA processing. WDR4 forms a complex with METTL1 (methyltransferase like 1), which is essential for the 7-methylguanosine modification of tRNA, a modification vital for proper translation and gene expression. Disruptions in WDR4 function can lead to significant cellular dysfunction and have been linked to developmental disorders such as Down syndrome, highlighting WDR4′s importance in maintaining cellular integrity and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WDR4 Antibody (321.9) References:
- The WD repeat: a common architecture for diverse functions. | Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
- Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. | Michaud, J., et al. 2000. Genomics. 68: 71-9. PMID: 10950928
- WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. | Li, D. and Roberts, R. 2001. Cell Mol Life Sci. 58: 2085-97. PMID: 11814058
- Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. | Alexandrov, A., et al. 2002. RNA. 8: 1253-66. PMID: 12403464
- The WD-40 repeat. | van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Olsen, JV., et al. 2006. Cell. 127: 635-48. PMID: 17081983
- The ancient regulatory-protein family of WD-repeat proteins. | Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
- Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit. | Garcia-Higuera, I., et al. 1996. Biochemistry. 35: 13985-94. PMID: 8909296
- Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13. | Garcia-Higuera, I., et al. 1998. J Biol Chem. 273: 9041-9. PMID: 9535892
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WDR4 Antibody (321.9) | sc-100894 | 100 µg/ml | $339.00 |