WAY-600 (CAS 1062159-35-6)
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WAY-600 is a potent ATP-competitive mTOR inhibitor with an IC50 of about 9 nM. It is well reported that the mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. WAY-600 has significant selectivity against mTOR over phosphatidylinositol 3-kinase (PI3K) isofoms (>100-fold). WAY-600 treated HEK293 cells indicated a 50% inhibition of polysomes by Way-600 compared with the 11% suppression by rapamycin. Unlike the rapalogs,WAY-600 acutely blocked mTORC2-dependent phosphorylation of AKT in vitro. In various cancer cells, WAY-600 inhibited the mTORC1 substrate P-S6K(T389) and mTORC2 substrate P-AKT(S473) at submicromolar concentrations without significant inhibition of P-AKT(T308).
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAY-600, 5 mg | sc-364648 | 5 mg | $405.00 | |||
WAY-600, 50 mg | sc-364648A | 50 mg | $1455.00 |