Molecular structure of WAY 213613, CAS Number: 868359-05-1
WAY 213613 (CAS 868359-05-1)
Alternate Names:
N4-[4-(2-Bromo-4,5-difluorophenoxy)phenyl)]-L-asparagine
Application:
WAY 213613 is a selective non-substrate inhibitor of EAAT2
CAS Number:
868359-05-1
Purity:
≥99%
Molecular Weight:
415.19
Molecular Formula:
C16H13BrF2N2O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
WAY 213613 is a chemical that functions as a selective antagonist at the 5-HT2C receptor. It acts by binding to the receptor and blocking the action of serotonin, a neurotransmitter that typically activates the receptor. This interaction inhibits the downstream signaling pathways that are normally activated by serotonin binding to the receptor. By doing so, WAY 213613 modulates the activity of the 5-HT2C receptor, which plays a role in regulating mood, appetite, and stress response. Way 213613′s mechanism of action involves targeting the 5-HT2C receptor and altering its function, which can be useful in studying the role of this receptor in various physiological processes.
WAY 213613 (CAS 868359-05-1) References
- Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. | Dunlop, J., et al. 2005. Mol Pharmacol. 68: 974-82. PMID: 16014807
- Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells. | Karatas-Wulf, U., et al. 2009. Neuroscience. 161: 794-805. PMID: 19364521
- Activity dependent internalization of the glutamate transporter GLT-1 mediated by β-arrestin 1 and ubiquitination. | Ibáñez, I., et al. 2016. Neuropharmacology. 107: 376-386. PMID: 27044663
- Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay. | Hashimoto, M., et al. 2018. ACS Chem Biol. 13: 1480-1486. PMID: 29851333
- Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors. | Fu, H., et al. 2018. J Med Chem. 61: 7741-7753. PMID: 30011368
- Control of Long-Term Plasticity by Glutamate Transporters. | Valtcheva, S. and Venance, L. 2019. Front Synaptic Neurosci. 11: 10. PMID: 31024287
- The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in Pseudomonas aeruginosa. | Kim, HJ., et al. 2020. J Biol Chem. 295: 10081-10091. PMID: 32404369
- β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs). | Liu, N., et al. 2020. ACS Med Chem Lett. 11: 2212-2220. PMID: 33214831
- Downregulation of astroglial glutamate transporter GLT-1 in the lateral habenula is associated with depressive-like behaviors in a rat model of Parkinson's disease. | Lyu, S., et al. 2021. Neuropharmacology. 196: 108691. PMID: 34197892
- Pharmacological evidence for the concept of spare glutamate transporters. | Belo do Nascimento, I., et al. 2021. Neurochem Int. 149: 105142. PMID: 34314789
- Structural basis of ligand binding modes of human EAAT2. | Zhang, Z., et al. 2022. Nat Commun. 13: 3329. PMID: 35680945
- Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury. | Hsu, PC., et al. 2022. Life Sci. 306: 120833. PMID: 35882273
- Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2. | Kato, T., et al. 2022. Nat Commun. 13: 4714. PMID: 35953475
Inhibitor of:
EAAT2, EAAT3, and EAAT5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAY 213613, 10 mg | sc-203720 | 10 mg | $199.00 | |||
| US: Only available in the US | ||||||
WAY 213613, 50 mg | sc-203720A | 50 mg | $842.00 | |||
| US: Only available in the US | ||||||