Molecular structure of WAY 208466 dihydrochloride, CAS Number: 633304-27-5
WAY 208466 dihydrochloride (CAS 633304-27-5)
Alternate Names:
3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
Application:
WAY 208466 dihydrochloride is a high affinity, selective SR-6 (5-HT6) agonist
CAS Number:
633304-27-5
Purity:
98%
Molecular Weight:
420.33
Molecular Formula:
C17H18FN3O2S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
WAY 208466 dihydrochloride is a compound extensively researched in neurochemistry for its role as an agonist of the serotonin 5-HT6 receptor. The compound′s interaction with this receptor subtype is of interest due to the receptor′s involvement in cognitive processes and neurotransmission regulation. Studies utilizing WAY 208466 dihydrochloride primarily focus on its effects on animal models to investigate the potential modulation of cognitive functions and to explore the underlying molecular pathways associated with the 5-HT6 receptor activity. Research with this compound contributes to a better understanding of the serotonergic system′s influence on learning, memory, and possibly mood regulation. Additionally, WAY 208466 dihydrochloride is used in pharmacological studies aiming to characterize the receptor′s pharmacokinetics and binding properties, which are for the design of compounds with improved efficacy and safety profiles.
WAY 208466 dihydrochloride (CAS 633304-27-5) References
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- Serotonin₆ receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats. | Liu, KC., et al. 2015. Neuropharmacology. 95: 290-8. PMID: 25863121
- Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats. | Jastrzębska-Więsek, M., et al. 2015. Naunyn Schmiedebergs Arch Pharmacol. 388: 1079-88. PMID: 26077660
- The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect. | Pytka, K., et al. 2016. Pharmacol Rep. 68: 263-74. PMID: 26922526
- Activation and blockade of serotonin6 receptors in the dorsal hippocampus enhance T maze and hole-board performance in a unilateral 6-hydroxydopamine rat model of Parkinson's disease. | Liu, KC., et al. 2016. Brain Res. 1650: 184-195. PMID: 27616337
- Spinal 5-HT4 and 5-HT6 receptors contribute to the maintenance of neuropathic pain in rats. | Pineda-Farias, JB., et al. 2017. Pharmacol Rep. 69: 916-923. PMID: 28628851
- Chronic antidepressant-like effect of EMD386088, a partial 5-HT6 receptor agonist, in olfactory bulbectomy model may be connected with BDNF and/or CREB signalling pathway. | Jastrzębska-Więsek, M., et al. 2018. Pharmacol Rep. 70: 1047-1056. PMID: 30292720
- Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement. | Teng, LL., et al. 2019. PLoS Biol. 17: e2007097. PMID: 30883547
- Activation and blockade of dorsal hippocampal Serotonin6 receptors regulate anxiety-like behaviors in a unilateral 6-hydroxydopamine rat model of Parkinson's disease. | Liu, KC., et al. 2019. Neurol Res. 41: 791-801. PMID: 31056008
- Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice. | Sugiyama, Y., et al. 2019. J Reprod Dev. 65: 541-550. PMID: 31694987
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Activator of:
Serotonin, and SR-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAY 208466 dihydrochloride, 10 mg | sc-361404 | 10 mg | $134.00 |