Molecular structure of WAY 100635 Hydrochloride, CAS Number: 146714-97-8
WAY 100635 Hydrochloride (CAS 146714-97-8)
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Alternate Names:
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide Trihydrochloride
Application:
WAY 100635 Hydrochloride is a potent 5-HT1A antagonist
CAS Number:
146714-97-8
Molecular Weight:
531.95
Molecular Formula:
C25H34N4O2•3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
WAY 100635 Hydrochloride is a selective antagonist at the 5-HT1A receptor, functioning by blocking the binding of serotonin to this receptor. WAY 100635 Hydrochloride exerts its mechanism of action by inhibiting the activation of the 5-HT1A receptor, thereby preventing downstream signaling pathways from being initiated. By targeting the 5-HT1A receptor, WAY 100635 Hydrochloride modulates serotonin neurotransmission in experimental models. It acts as a competitive antagonist, binding to the receptor with high affinity and specificity, thereby interfering with the normal physiological function of the receptor. Through this mechanism, WAY 100635 Hydrochloride is able to effectively block the effects of serotonin at the 5-HT1A receptor, making is a useful to investigate the role of this receptor in various experimental applications.
WAY 100635 Hydrochloride (CAS 146714-97-8) References
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- The serotonin-1A receptor antagonist WAY-100635 modifies fluoxetine's antidepressant-like profile on the differential reinforcement of low rates 72-s schedule in rats. | Cousins, MS. and Seiden, LS. 2000. Psychopharmacology (Berl). 148: 438-42. PMID: 10928318
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- Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. | Lucas, G., et al. 2007. Neuron. 55: 712-25. PMID: 17785179
- PET tracers for 5-HT(1A) receptors and uses thereof. | Kumar, JS. and Mann, JJ. 2007. Drug Discov Today. 12: 748-56. PMID: 17826688
- Further evidence for an antidepressant potential of the selective sigma1 agonist SA 4503: electrophysiological, morphological and behavioural studies. | Lucas, G., et al. 2008. Int J Neuropsychopharmacol. 11: 485-95. PMID: 18364064
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- Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT). | Fox, MA., et al. 2010. Br J Pharmacol. 159: 879-87. PMID: 20128812
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- Pharmacological studies of performance on the free-operant psychophysical procedure. | Body, S., et al. 2013. Behav Processes. 95: 71-89. PMID: 23428704
- Re-evaluation of the discriminative stimulus effects of lysergic acid diethylamide with male and female Sprague-Dawley rats. | Herr, KA. and Baker, LE. 2020. Behav Pharmacol. 31: 776-786. PMID: 32960851
- The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. | Mos, J., et al. 1997. Eur J Pharmacol. 325: 145-53. PMID: 9163561
Inhibitor of:
Serotonin, and SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAY 100635 Hydrochloride, 250 mg | sc-391296 | 250 mg | $367.00 |