Wang resin (CAS 201058-08-4)
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Wang resin is a solid support peptide synthesis. It functions as a linker, allowing for the attachment of amino acids during the stepwise assembly of peptides. The resin contains a reactive group that can form a covalent bond with the carboxyl group of the amino acid, facilitating the synthesis of peptide chains. The mechanism of action involves the activation of the carboxyl group of the incoming amino acid, which reacts with the reactive group on the resin, leading to the formation of a peptide bond. This allows for the efficient and controlled synthesis of peptides in a stepwise manner. Wang resin′s role in peptide synthesis is to provide a solid support for the growing peptide chain, enabling the isolation and purification of the desired peptide product.
Wang resin (CAS 201058-08-4) References
- Synthesis of diverse 4,5-dihydro-3(2H)-pyridazinones on Wang resin. | Gouault, N., et al. 2001. J Pharm Pharmacol. 53: 981-5. PMID: 11480550
- Wang resin-type linker containing a nitro group for polymer support oligosaccharide synthesis: polymer-supported glycosyl donor. | Manabe, S. and Ito, Y. 2001. Chem Pharm Bull (Tokyo). 49: 1234-5. PMID: 11558624
- Solid-phase synthesis of 5-isoxazol-4-yl-[1,2,4]oxadiazoles. | Quan, C. and Kurth, M. 2004. J Org Chem. 69: 1470-4. PMID: 14986998
- Solid-phase syntheses of 6-arylpyridazin-3(2H)-ones. | Salives, R., et al. 2005. J Comb Chem. 7: 414-20. PMID: 15877470
- Solid-phase synthesis of 3-aminopyrrole-2,5-dicarboxylate analogues. | Brouillette, Y., et al. 2006. J Comb Chem. 8: 117-26. PMID: 16398562
- Parallel solid-phase synthesis of diaryltriazoles. | Wrobel, M., et al. 2012. Beilstein J Org Chem. 8: 1027-36. PMID: 23019430
- Solid Phase Stepwise Synthesis of Polyethylene Glycols. | Khanal, A. and Fang, S. 2017. Chemistry. 23: 15133-15142. PMID: 28834652
- Design, Synthesis and Biological Evaluation of Novel Peptide-Like Analogues as Selective COX-2 Inhibitors. | Ahmaditaba, MA., et al. 2018. Iran J Pharm Res. 17: 87-92. PMID: 29755541
- Total Solid-Phase Synthesis of Dehydroxy Fengycin Derivatives. | Rosés, C., et al. 2018. J Org Chem. 83: 15297-15311. PMID: 30525634
- Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations. | Kwan, MHT., et al. 2021. J Org Chem. 86: 2458-2473. PMID: 33482690
- Synthesis of Polycyclic Tetrahydroisoquinolines and Tetrahydrobenzo[d]azepines from Polymer-Supported Allylglycine. | Králová, P. and Soural, M. 2022. J Org Chem. 87: 5242-5256. PMID: 35344355
- Synthesis of chiral 1,4-oxazepane-5-carboxylic acids from polymer-supported homoserine. | Králová, P., et al. 2020. RSC Adv. 10: 35906-35916. PMID: 35517075
- Wang resin catalysed sonochemical synthesis of pyrazolo[4,3-d]pyrimidinones and 2,3-dihydroquinazolin-4(1H)-ones: Identification of chorismate mutase inhibitors having effects on Mycobacterium tuberculosis cell viability. | Shukla, S., et al. 2023. Bioorg Chem. 134: 106452. PMID: 36889201
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wang resin, 5 g | sc-286858 | 5 g | $75.00 | |||
Wang resin, 25 g | sc-286858A | 25 g | $203.00 |