W146 trifluoroacetate salt (CAS 909725-62-8)
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W146 is a compound utilized in scientific research, particularly for its role as a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1P1). Studies involving W146 focus on elucidating the biological functions of S1P1, which include regulation of immune cell trafficking and vascular permeability. The compound is valuable for investigating the signaling pathways modulated by S1P1, allowing researchers to understand how this receptor contributes to physiological and pathological processes. W146 is also used in experiments designed to dissect the role of S1P1 in disease models, providing insights into how modulation of this receptor might influence disease progression. This compound′s antagonist properties are for understanding the complex network of receptor-mediated actions and their potential impact on health and disease.
W146 trifluoroacetate salt (CAS 909725-62-8) References
- Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway. | Hsu, CL. and Bryce, PJ. 2012. J Immunol. 189: 3421-9. PMID: 22922818
- Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. | Chimen, M., et al. 2015. Nat Med. 21: 467-475. PMID: 25894827
- The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. | Kim, SE., et al. 2016. Invest Ophthalmol Vis Sci. 57: 301-11. PMID: 26830367
- Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. | Ko, J., et al. 2017. Invest Ophthalmol Vis Sci. 58: 2544-2553. PMID: 28492873
- Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation. | Karunakaran, I., et al. 2019. Glia. 67: 1859-1872. PMID: 31231866
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
W146 trifluoroacetate salt, 500 µg | sc-296700 | 500 µg | $153.00 | |||
W146 trifluoroacetate salt, 1 mg | sc-296700A | 1 mg | $286.00 |