Molecular structure of W140 trifluoroacetate salt, CAS Number: 909725-64-0
W140 trifluoroacetate salt (CAS 909725-64-0)
CAS Number:
909725-64-0
Molecular Weight:
456.40
Molecular Formula:
C16H27N2O4P•C2F3HO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 (trifluoroacetate salt) is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 µM (2a = W146; 2b = W140 in supplemental material). It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.
W140 trifluoroacetate salt (CAS 909725-64-0) References
1 Takuwa, Y., Takuwa, N., Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. J Biochem 131 767-771 (2002). 2 Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receOrdering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
W140 trifluoroacetate salt, 500 µg | sc-296699 | 500 µg | $120.00 | |||
W140 trifluoroacetate salt, 1 mg | sc-296699A | 1 mg | $200.00 | |||
W140 trifluoroacetate salt, 5 mg | sc-296699B | 5 mg | $756.00 |