W-5 (CAS 61714-25-8)
See product citations (2)
QUICK LINKS
W-5, as a CaM antagonist, plays a role in the study of calcium signaling pathways by binding to calmodulin, a key calcium-binding messenger protein involved in the regulation of a wide array of cellular processes. By inhibiting the interaction between calmodulin and its target proteins, W-5 serves as a vital tool for understanding the mechanisms through which calcium ions and calmodulin mediate cellular activities. Specifically, the inhibition of MYLK (myosin light chain kinase) and PDE (Ca2+-calmodulin-dependent phosphodiesterase) by W-5, with IC50 values of 230 µM and 240 µM respectively, highlights its utility in dissecting the role of calmodulin in muscle contraction, cellular movement, and the breakdown of cyclic nucleotides within cells.
W-5 (CAS 61714-25-8) References
- Effect of calmodulin antagonists on auxin-induced elongation. | Raghothama, KG., et al. 1985. Plant Physiol. 79: 28-33. PMID: 16664387
- Involvement of Calmodulin and Calmodulin-Dependent Myosin Light Chain Kinase in Blue Light-Dependent H Pumping by Guard Cell Protoplasts from Vicia faba L. | Shimazaki, K., et al. 1992. Plant Physiol. 99: 1416-21. PMID: 16669053
- Calmodulin and insulin secretion: use of naphthalenesulfonamide compounds. | Yaney, GC. and Sharp, GW. 1990. Am J Physiol. 259: E856-64. PMID: 1701970
- The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer. | Berchtold, MW. and Villalobo, A. 2014. Biochim Biophys Acta. 1843: 398-435. PMID: 24188867
- Clearer demonstration of calcium/calmodulin-dependent events in synaptosomes by use of the differential effects of two calmodulin antagonists, N-(aminohexyl)-5-chloro-1-naphthalenesulfonamide and N-(6-aminohexyl)-1-naphthalenesulfonamide. | Imai, S. and Onozuka, M. 1988. Comp Biochem Physiol C Comp Pharmacol Toxicol. 91: 535-40. PMID: 2905967
- Inhibition of proliferative growth in glioma cells by calmodulin antagonists. | Suzuki, N., et al. 1986. J Neurosurg. 65: 74-9. PMID: 3712030
- The effects of several ion channel blockers and calmodulin antagonists on fertilization-induced acid release and 45Ca2+ uptake in sea urchin eggs. | Komukai, M., et al. 1985. Exp Cell Res. 159: 463-72. PMID: 4040867
- Naphthalenesulfonamides as calmodulin antagonists. | Hidaka, H. and Tanaka, T. 1983. Methods Enzymol. 102: 185-94. PMID: 6139736
- Effects of calmodulin antagonists on immune mouse lymphocytes. | Wolberg, G. and Zimmerman, TP. 1984. Mol Pharmacol. 26: 286-92. PMID: 6482875
- N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. | Hidaka, H., et al. 1981. Proc Natl Acad Sci U S A. 78: 4354-7. PMID: 6945588
- Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives. | Hidaka, H., et al. 1981. Mol Pharmacol. 20: 571-8. PMID: 7329399
- Regulation of flagellar motility of fowl spermatozoa: evidence for the involvement of intracellular free Ca2+ and calmodulin. | Ashizawa, K., et al. 1994. J Reprod Fertil. 101: 265-72. PMID: 7932358
- Calmodulin antagonists increase the expression of membrane-type-1 matrix metalloproteinase in human uterine cervical fibroblasts. | Ito, A., et al. 1998. Eur J Biochem. 251: 353-8. PMID: 9492304
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
W-5, 25 mg | sc-201500 | 25 mg | $68.00 | |||
W-5, 500 mg | sc-201500A | 500 mg | $656.00 |