VZV Immediate Early Protein Antibody (8B11): sc-56998

VZV Immediate Early Protein Antibody (8B11) is a mouse monoclonal IgG1 antibody that detects VZV Immediate Early Protein of Varicella Zoster Virus origin by immunofluorescence (IF). Anti-VZV Immediate Early Protein antibody (8B11) is available as a non-conjugated format. The Varicella-zoster virus (VZV) causes two significant diseases: childhood chickenpox (varicella) and shingles (zoster). Once contracted, VZV can become dormant in sensory ganglia, potentially reactivating years later to cause shingles. VZV Immediate Early Protein, also known as IE62, ORF 62, or IE175, serves as a crucial transactivator in the viral lifecycle, playing a vital role in viral pathogenesis by promoting neuron survival during both primary and reactivated infections. VZV Immediate Early Protein is primarily localized in the nucleus of transfected and VZV-infected cells, where ORF 66 protein regulates activity. The cellular transcription factor Sp1 interacts with VZV Immediate Early Protein, facilitating recruitment to the gI promoter, which is essential for viral replication. VZV Immediate Early Protein enhances the binding of Sp1 and the cellular factor TATA-binding protein (TBP), underscoring importance in the transcriptional regulation of viral genes.

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VZV Immediate Early Protein Antibody (8B11) References:

1. Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins.  |  Lynch, JM., et al. 2002. Virology. 302: 71-82. PMID: 12429517
2. Identification of CD8+ T cell epitopes in the immediate early 62 protein (IE62) of varicella-zoster virus, and evaluation of frequency of CD8+ T cell response to IE62, by use of IE62 peptides after varicella vaccination.  |  Frey, CR., et al. 2003. J Infect Dis. 188: 40-52. PMID: 12825169
3. Interaction between the varicella zoster virus IE62 major transactivator and cellular transcription factor Sp1.  |  Peng, H., et al. 2003. J Biol Chem. 278: 38068-75. PMID: 12855699
4. Transcription factor USF, expressed during the entire phase of varicella-zoster virus infection, interacts physically with the major viral transactivator IE62 and plays a significant role in virus replication.  |  Rahaus, M., et al. 2003. J Gen Virol. 84: 2957-2967. PMID: 14573800
5. The varicella-zoster virus-mediated delayed host shutoff: open reading frame 17 has no major function, whereas immediate-early 63 protein represses heterologous gene expression.  |  Desloges, N., et al. 2005. Microbes Infect. 7: 1519-29. PMID: 16039898
6. Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.  |  Garry, EM., et al. 2005. Pain. 118: 97-111. PMID: 16213091
7. Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons.  |  Hood, C., et al. 2006. J Virol. 80: 1025-31. PMID: 16379003
8. Promoter activation by the varicella-zoster virus major transactivator IE62 and the cellular transcription factor USF.  |  Yang, M., et al. 2006. J Virol. 80: 7339-53. PMID: 16840315
9. Regulated nuclear localization of the varicella-zoster virus major regulatory protein, IE62.  |  Kinchington, PR. and Turse, SE. 1998. J Infect Dis. 178 Suppl 1: S16-21. PMID: 9852967

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VZV Immediate Early Protein Antibody (8B11) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VZV Immediate Early Protein Antibody (8B11) Specifications

Alternate Product Name: VZV Immediate Early Protein

Product Clone Name: 8B11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: VZV Immediate Early Protein

Epitope Species: Varicella Zoster virus

Product Reactivity/Detection: Immediate Early Protein

Species Reactivity/Detection: Varicella Zoster Virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for VZV Immediate Early Protein Antibody (8B11): N/A