VZV gB Antibody (10G6): sc-56993

VZV gB Antibody (10G6) is a mouse monoclonal IgG1 antibody that detects the VZV gB protein of Varicella Zoster Virus origin by immunofluorescence (IF). Anti-VZV gB antibody (10G6) is available as the non-conjugated format. The Varicella Zoster Virus (VZV) causes two significant diseases: childhood chickenpox (varicella) and shingles (zoster). Understanding VZV gB protein structure is crucial, as VZV gB protein plays a vital role in viral infection of host cells. VZV gB functions as a type I membrane glycoprotein essential for viral entry and fusion with host cell membranes. Multiple domains within VZV gB facilitate interactions with other viral proteins and host cell receptors, critical for viral lifecycle. Three consensus internalization motifs within VZV gB′s cytoplasmic domain enable efficient internalization and subsequent Golgi apparatus localization, mediated by specific tyrosine-based sequence motifs. This structural feature aids in viral replication and influences pathogenicity, making VZV gB an important target for therapeutic interventions and vaccine development.

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VZV gB Antibody (10G6) References:

1. Essential role played by the C-terminal domain of glycoprotein I in envelopment of varicella-zoster virus in the trans-Golgi network: interactions of glycoproteins with tegument.  |  Wang, ZH., et al. 2001. J Virol. 75: 323-40. PMID: 11119602
2. Varicella-Zoster virus infections of the nervous system: clinical and pathologic correlates.  |  Kleinschmidt-DeMasters, BK. and Gilden, DH. 2001. Arch Pathol Lab Med. 125: 770-80. PMID: 11371229
3. VZV gB endocytosis and Golgi localization are mediated by YXXphi motifs in its cytoplasmic domain.  |  Heineman, TC. and Hall, SL. 2001. Virology. 285: 42-9. PMID: 11414804
4. Varicella-zoster virus glycoproteins E and I expressed in insect cells form a heterodimer that requires the N-terminal domain of glycoprotein I.  |  Kimura, H., et al. 1997. Virology. 233: 382-91. PMID: 9217061
5. Mutational analysis of the role of glycoprotein I in varicella-zoster virus replication and its effects on glycoprotein E conformation and trafficking.  |  Mallory, S., et al. 1997. J Virol. 71: 8279-88. PMID: 9343180
6. Varicella-zoster virus glycoprotein I is essential for growth of virus in Vero cells.  |  Cohen, JI. and Nguyen, H. 1997. J Virol. 71: 6913-20. PMID: 9261418
7. Transcription factor Sp1 is involved in the regulation of varicella-zoster virus glycoprotein E.  |  Rahaus, M. and Wolff, MH. 2000. Virus Res. 69: 69-81. PMID: 10989187

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VZV gB Antibody (10G6) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VZV gB Antibody (10G6) Specifications

Alternate Product Name: VZV gB

Product Clone Name: 10G6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: VZV gB

Epitope Species: Varicella Zoster virus

Product Reactivity/Detection: glycoprotein B

Species Reactivity/Detection: Varicella Zoster Virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for VZV gB Antibody (10G6): N/A