Molecular structure of VX-222, CAS Number: 1026785-55-6
VX-222 (CAS 1026785-55-6)
Alternate Names:
Lomibuvir; VCH-222
Application:
VX-222 is an inhibitor of HCV NS5B 1a and HCV NS5B 1b
CAS Number:
1026785-55-6
Purity:
≥98%
Molecular Weight:
445.61
Molecular Formula:
C25H35NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
VX-222 (VCH-222) is a novel, potent and selective inhibitor of non-nucleoside polymerase of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, with an IC50 range of 0.94-1.2 μM. VX-222 binding occurs at the HCV RNA-dependent RNA polymerase thumb II allosteric pocket. VX-222 shows both noncompetitive and selective inhibition of Nopp140. VX-222 selectively inhibits the replication of subgenomic HCV genotype 1a and 1b. VX-222 inhibits the subgenomic replicon of 1b/Con1 HCV. VX-222, shows only a modest or no effect on de novo-initiated RNA synthesis, but preferentially inhibits primer-dependent RNA synthesis.
Inhibitor of:
Enzyme, Hep C NS5b, and Nopp140.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VX-222, 5 mg | sc-364646 | 5 mg | $191.00 | |||
VX-222, 200 mg | sc-364646A | 200 mg | $3749.00 |