VX-222 CAS: 1026785-55-6
MF: C25H35NO4S
MW: 445.61
An inhibitor of HCV NS5B 1a and HCV NS5B 1b.

VX-222 (CAS 1026785-55-6)

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Alternate Names: Lomibuvir; VCH-222
Application: VX-222 is an inhibitor of HCV NS5B 1a and HCV NS5B 1b
CAS Number: 1026785-55-6
Purity: ≥98%
Molecular Weight: 445.61
Molecular Formula: C25H35NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

VX-222 (VCH-222) is a novel, potent and selective inhibitor of non-nucleoside polymerase of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, with an IC50 range of 0.94-1.2 μM. VX-222 binding occurs at the HCV RNA-dependent RNA polymerase thumb II allosteric pocket. VX-222 shows both noncompetitive and selective inhibition of Nopp140. VX-222 selectively inhibits the replication of subgenomic HCV genotype 1a and 1b. VX-222 inhibits the subgenomic replicon of 1b/Con1 HCV. VX-222, shows only a modest or no effect on de novo-initiated RNA synthesis, but preferentially inhibits primer-dependent RNA synthesis.

Physical State :
Solid
Solubility :
Soluble in DMSO (89 mg/ml), ethanol (89 mg/ml), and water (< 1 mg/ml at 25 °C).
Storage :
Store at -20° C
IC50 :
1b/Con1 HCV subgenomic replicon: EC5050 = 5 nM; Replication of subgenomic HCV genotype 1b: EC5050 = 11.2 nM; Replication of subgenomic HCV genotype 1a: EC5050 = 22.3 nM; HCV NS5B 1a: IC50 = 0.94 µM; HCV NS5B 1b: IC50 = 1.2 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24798764
MDL Number :
MFCD18089858
SMILES :
CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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