Molecular structure of Vulpinic acid, CAS Number: 521-52-8
Vulpinic acid (CAS 521-52-8)
Alternate Names:
(αE)-α-(3-Hydroxy-5-oxo-4-phenyl-2(5H)-furanylidene)benzeneacetic Acid Methyl Ester; 3,4-Dihydroxy-2,5-Diphenyl-2,4-hexadienedioic Acid Methyl Ester 3,6-Lactone
Application:
Vulpinic acid is a lichen metabolite with anti-inflammatory properties
CAS Number:
521-52-8
Purity:
≥98%
Molecular Weight:
322.31
Molecular Formula:
C19H14O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Vulpinic Acid is a lichen metabolite with anti-inflammatory properties. Vulpinic acid, a lichen metabolite present in L. vulpina, possesses a wide range of biological activities. It exhibits activity against various bacteria including C. perfringens, B. vulgatus, B. fragilis, B. loescheii, P. acnes, E. faecium, as well as methicillin-susceptible and -resistant S. aureus, with minimum inhibitory concentrations (MICs) ranging from 4 to 16 μg/ml. Additionally, Vulpinic acid (25-800 μM) protects HaCaT human keratinocytes from UVB-induced apoptosis, cytotoxicity, and cytoskeletal modifications, while promoting scratch wound healing in these cells.
Vulpinic acid (CAS 521-52-8) References
- Letharia vulpina, a vulpinic acid containing lichen, targets cell membrane and cell division processes in methicillin-resistant Staphylococcus aureus. | Shrestha, G., et al. 2016. Pharm Biol. 54: 413-8. PMID: 25919857
- Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid. | Koparal, AT. 2015. Z Naturforsch C J Biosci. 70: 159-64. PMID: 26136299
- A chemogenomic approach to understand the antifungal action of Lichen-derived vulpinic acid. | Kwon, Y., et al. 2016. J Appl Microbiol. 121: 1580-1591. PMID: 27660105
- Determination of Vulpinic Acid Effect on Apoptosis and mRNA Expression Levels in Breast Cancer Cell Lines. | Kılıç, N., et al. 2018. Anticancer Agents Med Chem. 18: 2032-2041. PMID: 30179144
- Why chartreuse? The pigment vulpinic acid screens blue light in the lichen Letharia vulpina. | Phinney, NH., et al. 2019. Planta. 249: 709-718. PMID: 30374913
- Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis. | Sahin, E., et al. 2019. Hum Exp Toxicol. 38: 675-684. PMID: 30868920
- Vulpinic acid as a natural compound inhibits the proliferation of metastatic prostate cancer cells by inducing apoptosis. | Cansaran-Duman, D., et al. 2021. Mol Biol Rep. 48: 6025-6034. PMID: 34331181
- Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes. | Demir, Y., et al. 2022. J Biomol Struct Dyn. 40: 12008-12021. PMID: 34424822
- The role of vulpinic acid as a natural compound in the regulation of breast cancer-associated miRNAs. | Cansaran-Duman, D., et al. 2021. Biol Res. 54: 37. PMID: 34743742
- Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways. | Mohammadi, M., et al. 2022. Chem Biol Interact. 351: 109768. PMID: 34864007
- Anti-ageing and Anti-lung Carcinoma Effects of Vulpinic Acid and Usnic Acid Compounds and Biological Investigations with Molecular Modeling Study. | Wu, Y., et al. 2022. J Oleo Sci. 71: 247-255. PMID: 35110467
- The molecular mechanisms of vulpinic acid induced programmed cell death in melanoma. | Yangın, S., et al. 2022. Mol Biol Rep. 49: 8273-8280. PMID: 35960408
- In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms. | Lauterwein, M., et al. 1995. Antimicrob Agents Chemother. 39: 2541-3. PMID: 8585741
Inhibitor of:
α-actinin-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vulpinic acid, 100 mg | sc-213164A | 100 mg | $270.00 | |||
Vulpinic acid, 250 mg | sc-213164 | 250 mg | $468.00 | |||
Vulpinic acid, 1 g | sc-213164B | 1 g | $2029.00 | |||
Vulpinic acid, 2.5 g | sc-213164C | 2.5 g | $4110.00 |