Molecular structure of VUF 5681 dihydrobromide, CAS Number: 639089-06-8
VUF 5681 dihydrobromide (CAS 639089-06-8)
Alternate Names:
4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide
Application:
VUF 5681 dihydrobromide is a potent histamine H3-receptor silent antagonist
CAS Number:
639089-06-8
Molecular Weight:
355.11
Molecular Formula:
C11H19N3•2HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
VUF 5681 dihydrobromide (VUF-5681) this novel compound serves as a small molecule inhibitor of phosphatidylinositol-3-kinase (PI3K), a key enzyme responsible for regulating cell growth and differentiation. The inhibition of PI3K activity lies at the core of VUF 5681 dihydrobromide′s functionality. By binding to the PI3K enzyme, it effectively hinders its activity, leading to a subsequent decrease in the functionality of downstream signaling pathways. This disruption of signaling cascades contributes to the observed decrease in cell growth and differentiation regulated by PI3K.
VUF 5681 dihydrobromide (CAS 639089-06-8) References
- Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. | Moreno-Delgado, D., et al. 2006. Neuropharmacology. 51: 517-23. PMID: 16769092
- Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | Baker, JG. 2008. BMC Pharmacol. 8: 9. PMID: 18538007
- Histamine inhibits the melanin-concentrating hormone system: implications for sleep and arousal. | Parks, GS., et al. 2014. J Physiol. 592: 2183-96. PMID: 24639485
- Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination. | Chen, Y., et al. 2017. PLoS One. 12: e0189380. PMID: 29253893
- Activation of orexinergic and histaminergic pathway involved in therapeutic effect of histamine H4 receptor antagonist against cisplatin-induced anorexia in mice. | Yamamoto, K., et al. 2019. Naunyn Schmiedebergs Arch Pharmacol. 392: 925-936. PMID: 30919010
Inhibitor of:
Histamine H3 Receptor.Activator of:
Histamine H3 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VUF 5681 dihydrobromide, 10 mg | sc-204389 | 10 mg | $165.00 | |||
VUF 5681 dihydrobromide, 50 mg | sc-204389A | 50 mg | $700.00 |