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VUF 5681 dihydrobromide is a potent histamine H3 receptor silent antagonist (pKi = 8.35).
Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414. Leurs et al (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat.Rev.Drug Discov. 4 107. Moreno-Delgado et al (2006) Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517.
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