VUF 5681 dihydrobromide CAS: 639089-06-8
MF: C11H19N3•2HBr
MW: 355.11
A potent histamine H3-receptor silent antagonist.

VUF 5681 dihydrobromide (CAS 639089-06-8)

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Synonym: 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide
Application: A potent histamine H3-receptor silent antagonist
CAS Number: 639089-06-8
Molecular Weight: 355.11
Molecular Formula: C11H19N32HBr
* Refer to Certificate of Analysis for lot specific data (including water content).
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VUF 5681 dihydrobromide is a potent histamine H3 receptor silent antagonist (pKi = 8.35).


References

Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414. Leurs et al (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat.Rev.Drug Discov. 4 107. Moreno-Delgado et al (2006) Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
53440140
MDL Number :
MFCD08668977
SMILES :
C1CNCCC1CCCC2=CN=CN2.Br.Br

Download SDS (MSDS)

Certificate of Analysis

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