VU 590 dihydrochloride CAS: 313505-85-0
MF: C24H32N4O7•2HCl•xH2O
MW: 561.46 (anhydrous)
An inhibitor of the renal, outer medullary potassium channel, KIR7.1.

VU 590 dihydrochloride (CAS 313505-85-0)

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Alternate Names: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
Application: VU 590 dihydrochloride is an inhibitor of the renal, outer medullary potassium channel, KIR7.1
CAS Number: 313505-85-0
Purity: ≥97%
Molecular Weight: 561.46 (anhydrous)
Molecular Formula: C24H32N4O72HCl•xH2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

VU 590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (ROMK, KIR1.1) while also able to inhibit the inward rectifying potassium channel KIR7.1. This comppound is also reported to not display an effect towards KIR2.1 or KIR4.1 and additionally acts as an intracellular ROMK channel pore blocker.


References

1. Lewis, L.M., et al. 2009. Mol. Pharmacol. 76: 1094-1103. PMID: 19706730

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Desiccate at -20° C
IC50 :
Kir1.1, ROMK: IC50 = 294 nM (renal)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1COCCN(CCOCCOCCN1CC2=CC=C(C=C2)[N+](=O)[O-])CC3=CC=C(C=C3)[N+](=O)[O-].Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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