Molecular structure of VU 152100, CAS Number: 409351-28-6
VU 152100 (CAS 409351-28-6)
Alternate Names:
ML 108; VU0152100
Application:
VU 152100 is a positive allosteric modulator of muscarinic choline receptor M4
CAS Number:
409351-28-6
Molecular Weight:
341.43
Molecular Formula:
C18H19N3O2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Has been shown to induce a 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.
VU 152100 (CAS 409351-28-6) References
- Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. | Brady, AE., et al. 2008. J Pharmacol Exp Ther. 327: 941-53. PMID: 18772318
- A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. | Shirey, JK., et al. 2009. J Neurosci. 29: 14271-86. PMID: 19906975
- New technologies enabling the industrialization of allosteric modulator discovery. | Lütjens, R., et al. 2013. Drug Discov Today Technol. 10: e253-60. PMID: 24050276
- Development of allosteric modulators of GPCRs for treatment of CNS disorders. | Nickols, HH. and Conn, PJ. 2014. Neurobiol Dis. 61: 55-71. PMID: 24076101
- Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. | Bubser, M., et al. 2014. ACS Chem Neurosci. 5: 920-42. PMID: 25137629
- Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber). | Jørgensen, KB., et al. 2016. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 202: 7-15. PMID: 26520141
- Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents. | Cieślik, P., et al. 2018. Psychopharmacology (Berl). 235: 2897-2913. PMID: 30054675
- Simultaneous activation of muscarinic and GABAB receptors as a bidirectional target for novel antipsychotics. | Cieślik, P., et al. 2019. Behav Brain Res. 359: 671-685. PMID: 30267715
- Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia. | Nicoletti, F., et al. 2019. Front Psychiatry. 10: 49. PMID: 30890967
- Reversal of MK-801-Induced Disruptions in Social Interactions and Working Memory with Simultaneous Administration of LY487379 and VU152100 in Mice. | Cieślik, P., et al. 2019. Int J Mol Sci. 20: PMID: 31174329
- Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency. | Heins-Marroquin, U., et al. 2019. Brain Commun. 1: fcz019. PMID: 32954262
- Serotonergic-Muscarinic Interaction within the Prefrontal Cortex as a Novel Target to Reverse Schizophrenia-Related Cognitive Symptoms. | Cieślik, P., et al. 2021. Int J Mol Sci. 22: PMID: 34445318
- Behavioral features and disorganization of oscillatory activity in C57BL/6J mice after acute low dose MK-801 administration. | Cui, K., et al. 2022. Front Neurosci. 16: 1001869. PMID: 36188453
Activator of:
mAChR M4.Substrate of:
mAChR M.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VU 152100, 5 mg | sc-311554 | 5 mg | $98.00 | |||
VU 152100, 25 mg | sc-311554A | 25 mg | $384.00 |