Molecular structure of VU 10010, CAS Number: 633283-39-3
VU 10010 (CAS 633283-39-3)
Application:
VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptors
CAS Number:
633283-39-3
Molecular Weight:
345.85
Molecular Formula:
C17H16ClN3OS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity coupling to G-proteins and for ACh.
VU 10010 (CAS 633283-39-3) References
- An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. | Shirey, JK., et al. 2008. Nat Chem Biol. 4: 42-50. PMID: 18059262
- Synaptic muscarinic response types in hippocampal CA1 interneurons depend on different levels of presynaptic activity and different muscarinic receptor subtypes. | Bell, LA., et al. 2013. Neuropharmacology. 73: 160-73. PMID: 23747570
- Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes. | Odagaki, Y., et al. 2014. J Pharmacol Sci. 125: 157-68. PMID: 24849282
- Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. | Bell, LA., et al. 2015. Front Cell Neurosci. 9: 115. PMID: 25918499
- Presynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus. | de Vin, F., et al. 2015. Brain Res. 1629: 260-9. PMID: 26505913
Activator of:
mAChR M4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VU 10010, 5 mg | sc-204387 | 5 mg | $80.00 | |||
VU 10010, 25 mg | sc-204387A | 25 mg | $323.00 |