VU 0364739 hydrochloride (CAS 1244640-48-9)
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Available in US only.
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VU 0364739 hydrochloride is a chemical compound widely utilized in scientific research for its potential to modulate neurotransmitter systems and investigate neurological disorders. Its mechanism of action primarily involves the allosteric modulation of metabotropic glutamate receptor subtype 5 (mGluR5), a G protein-coupled receptor (GPCR) involved in synaptic transmission and plasticity. By acting as a negative allosteric modulator (NAM) of mGluR5, VU 0364739 hydrochloride inhibits the receptor′s signaling pathway, leading to decreased intracellular calcium mobilization and downstream effects on synaptic transmission and neuronal excitability. In research, this compound has been instrumental in elucidating the role of mGluR5 in various neurological conditions, including schizophrenia, Alzheimer′s disease, Parkinson′s disease, and addiction. Additionally, studies have utilized VU 0364739 hydrochloride to explore the potential of targeting mGluR5 in the these disorders. Furthermore, its use extends to investigating the neurobiological mechanisms underlying synaptic plasticity, learning, and memory. As research in neuroscience continues to advance, VU 0364739 hydrochloride remains a valuable tool for probing the intricacies of neuronal function and identifying potential targets for neurological disorders.
VU 0364739 hydrochloride (CAS 1244640-48-9) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VU 0364739 hydrochloride, 10 mg | sc-363292 | 10 mg | $408.00 | |||
| US: Only available in the US | ||||||
VU 0364739 hydrochloride, 50 mg | sc-363292A | 50 mg | $2040.00 | |||
| US: Only available in the US | ||||||