Molecular structure of VU 0361737, CAS Number: 1161205-04-4
VU 0361737 (CAS 1161205-04-4)
Alternate Names:
N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Application:
VU 0361737 is a selective positive allosteric modulator at mGluR-4
CAS Number:
1161205-04-4
Molecular Weight:
262.69
Molecular Formula:
C13H11CIN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A selective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Also a brain penetrant.
VU 0361737 (CAS 1161205-04-4) References
- Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). | Engers, DW., et al. 2009. J Med Chem. 52: 4115-8. PMID: 19469556
- Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). | Engers, DW., et al. 2010. Bioorg Med Chem Lett. 20: 5175-8. PMID: 20667732
- Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄. | Cheung, YY., et al. 2011. ACS Comb Sci. 13: 159-65. PMID: 21338051
- Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders. | Célanire, S. and Campo, B. 2012. Expert Opin Drug Discov. 7: 261-80. PMID: 22468956
- Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. | Robichaud, AJ., et al. 2011. ACS Chem Neurosci. 2: 433-49. PMID: 22860170
- Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders. | Conn, PJ., et al. 2014. Nat Rev Drug Discov. 13: 692-708. PMID: 25176435
- Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. | Lindsley, CW., et al. 2016. Chem Rev. 116: 6707-41. PMID: 26882314
- ABI5 Is a Regulator of Seed Maturation and Longevity in Legumes. | Zinsmeister, J., et al. 2016. Plant Cell. 28: 2735-2754. PMID: 27956585
- Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State. | Jantas, D., et al. 2018. Basic Clin Pharmacol Toxicol. 123: 443-451. PMID: 29753314
- Allosteric Molecular Switches in Metabotropic Glutamate Receptors. | Orgován, Z., et al. 2021. ChemMedChem. 16: 81-93. PMID: 32686363
- New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties. | Stankiewicz, A., et al. 2022. J Enzyme Inhib Med Chem. 37: 211-225. PMID: 34894953
- A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism. | Lage-Rupprecht, V., et al. 2022. Patterns (N Y). 3: 100433. PMID: 35510183
- Group III metabotropic glutamate receptors as promising targets for neuroprotective therapy: Particular emphasis on the role of mGlu4 and mGlu7 receptors. | Domin, H. 2022. Pharmacol Biochem Behav. 219: 173452. PMID: 36030890
Inhibitor of:
mGluR-5.Activator of:
mGluR-4.Substrate of:
mGluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VU 0361737, 10 mg | sc-301976 | 10 mg | $115.00 | |||
VU 0361737, 50 mg | sc-301976A | 50 mg | $440.00 |