VU 0361737 CAS: 1161205-04-4
VU 0361737 is a selective positive allosteric modulator at mGluR-4.

VU 0361737 (CAS 1161205-04-4)

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Alternate Names: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Application: VU 0361737 is a selective positive allosteric modulator at mGluR-4
CAS Number: 1161205-04-4
Molecular Weight: 262.69
Molecular Formula: C13H11CIN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGluR-1, mGluR-2, mGluR-3, mGluR-6 and mGluR-7 receptors and displays weak activity at mGluR-5 and mGluR-8 receptors. Also a brain penetrant.


References

Engers et al (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J.Med.Chem. 52 4415.

Physical State :
Solid
Solubility :
DMSO (100mM)
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44191096
SMILES :
COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl

Download SDS (MSDS)

Certificate of Analysis

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