VSX1 Antibody (G-11): sc-393699

VSX1 Antibody (G-11) is a mouse monoclonal IgG3 kappa light chain antibody that detects VSX1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-VSX1 antibody (G-11) is available as the non-conjugated form. Visual system homeobox gene 1 (VSX1) plays a crucial role in retina and craniofacial structure development, making VSX1 essential for proper ocular development. VSX1 is predominantly located in the inner nuclear layer of the retina, where VSX1 is first detected in bipolar cells five days postnatal in mice. VSX1 expression in the retina is vital for retinal neuron differentiation and function, and VSX1 presence in embryonic craniofacial structures underscores VSX1′s importance in developmental biology. Additionally, human VSX1 gene, located on chromosome 20p11.21, encodes a 365 amino acid protein with five known splice variants, and VSX1 mutations are associated with corneal dystrophies such as posterior polymorphous dystrophy and keratoconus. VSX1′s ability to interact with other proteins involved in retinal signaling pathways further highlights VSX1′s significance in maintaining retinal health and function.

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VSX1 Antibody (G-11) References:

1. Isolation and characterization of a novel human paired-like homeodomain-containing transcription factor gene, VSX1, expressed in ocular tissues.  |  Semina, EV., et al. 2000. Genomics. 63: 289-93. PMID: 10673340
2. RINX(VSX1), a novel homeobox gene expressed in the inner nuclear layer of the adult retina.  |  Hayashi, T., et al. 2000. Genomics. 67: 128-39. PMID: 10903837
3. Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells.  |  Chow, RL., et al. 2001. Mech Dev. 109: 315-22. PMID: 11731243
4. VSX1: a gene for posterior polymorphous dystrophy and keratoconus.  |  Héon, E., et al. 2002. Hum Mol Genet. 11: 1029-36. PMID: 11978762

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VSX1 Antibody (G-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-VSX1 Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VSX1 Antibody (G-11) Specifications

Alternate Product Name: VSX1

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 309-332

Epitope Target: VSX1

Epitope Species: human

Product Reactivity/Detection: VSX1 L1 isoform

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for VSX1 Antibody (G-11): P: Blocking Peptide