VRK1 Antibody (1F6): sc-101554
- VRK1 Antibody (1F6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant VRK1 of human origin
- recommended for detection of VRK1 of mouse, rat and human origin by WB and IP
- m-IgG1 BP-HRP is the preferred secondary detection reagent for VRK1 Antibody (1F6) for WB applications. This reagent is now offered in a bundle with VRK1 Antibody (1F6) (see ordering information below).
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VRK1 Antibody (1F6) is a mouse monoclonal IgG1 antibody that detects VRK1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Anti-VRK1 antibody (1F6) recognizes human vaccina-related kinase 1, a crucial serine/threonine kinase that plays a significant role in cellular stress responses by phosphorylating key transcription factors, including p53 and c-Jun. The phosphorylation of p53 by VRK1 at Thr18 disrupts the interaction between p53 and its negative regulator, Mdm2, thereby stabilizing p53 and enhancing tumor suppressor functions. VRK1′s ability to phosphorylate c-Jun at Ser63 and Ser73 activates c-Jun-dependent transcription, which is vital for regulating various cellular processes, including proliferation and apoptosis. VRK1 localization in the nucleus is essential for direct interaction with transcription factors and other nuclear proteins, thereby influencing gene expression in response to stress signals. Through forming stable complexes with proteins like ATF2, VRK1 is integral to the cellular response to stress, making VRK1 monoclonal antibody (1F6) a valuable tool for researchers studying these critical pathways in cancer and other diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VRK1 Antibody (1F6) | sc-101554 | 200 µg/ml | $322.00 | |||
VRK1 Antibody (1F6): m-IgG1 BP-HRP Bundle | sc-542633 | 200 µg Ab; 20 µg BP | $361.00 |