Molecular structure of VPC 23019, CAS Number: 449173-19-7
VPC 23019 (CAS 449173-19-7)
See product citations (4)
Alternate Names:
2-Amino-N-(3-octylphenyl)-3-(phosph onooxy)-propanamaide
Application:
VPC 23019 is an antagonist of the EDG(sphingosine-1-phosphate receptor)
CAS Number:
449173-19-7
Molecular Weight:
372.40
Molecular Formula:
C17H29N2O5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
VPC 23019 is an EDG (sphingosine-1-phosphate receptor) antagonist that selectively inhibits EDG-1 (sphingosine-1-phosphate receptor 1 pKi = 7.86) and EDG-3 (sphingosine-1-phosphate receptor 3 pKi =5.93). It has also been shown to inhibit the growth of several types of cancer cells, including breast, prostate, and lung cancer cells. In addition, it has been used as an inhibitor of the enzyme PI3K, which is involved in the regulation of cell growth and differentiation.
VPC 23019 (CAS 449173-19-7) References
- Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells. | Balthasar, S., et al. 2006. Biochem J. 398: 547-56. PMID: 16753042
- S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. | Park, KS., et al. 2007. Biochem Biophys Res Commun. 356: 239-44. PMID: 17349972
- Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins. | Kim, MK., et al. 2007. Exp Mol Med. 39: 185-94. PMID: 17464180
- Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways. | Brizuela, L., et al. 2007. J Lipid Res. 48: 2264-74. PMID: 17609523
- Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature. | Lee, JF., et al. 2009. Am J Physiol Heart Circ Physiol. 296: H33-42. PMID: 19011048
- Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway. | Zhou, Y., et al. 2010. Stroke. 41: 1521-7. PMID: 20508187
- Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. | Lee, SY., et al. 2011. Nephrology (Carlton). 16: 163-73. PMID: 21272128
- Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model. | Mousseau, Y., et al. 2012. Breast Cancer Res Treat. 134: 31-40. PMID: 22160641
- PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. | Koch, A., et al. 2013. Biochim Biophys Acta. 1831: 1634-43. PMID: 23906789
- FTY720 mitigates torsion/detorsion-induced testicular injury in rats. | Shih, HJ., et al. 2015. J Surg Res. 196: 325-31. PMID: 25862489
- Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. | Li, C., et al. 2015. J Neuroinflammation. 12: 70. PMID: 25880547
- Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity. | Malik, FA., et al. 2015. PLoS One. 10: e0130313. PMID: 26079370
- Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice. | Kitada, Y., et al. 2016. Endocrinology. 157: 1839-51. PMID: 26943364
- Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice. | Kurano, M., et al. 2019. FASEB J. 33: 5181-5195. PMID: 30629456
- Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling Gαi/Gαs Conversion. | Wang, RH., et al. 2020. Front Pharmacol. 11: 584176. PMID: 33363467
Inhibitor of:
E130203B14Rik, EDG-1, EDG-3, LYPLA1, MFSD2B, OR6B1, and SPHKAP.Activator of:
ACP6, EDG-5, EDG-6, GPR55, neugrin, SO, and SPNS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VPC 23019, 10 mg | sc-362817 | 10 mg | $357.00 |