VPAC2 Antibody (AS69): sc-52795
- VPAC2 Antibody (AS69) is a mouse monoclonal IgG1, cited in 4 publications, provided at 50 µg/500 µl
- raised against amino acids 105-122 of VPAC2 of human origin
- recommended for detection of VPAC2 of mouse, rat and human origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for VPAC2 Antibody (AS69). This work is in progress.
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VPAC2 Antibody (AS69) is a mouse monoclonal IgG1 antibody that detects vasoactive intestinal peptide receptor 2 (VPAC2) in mouse, rat, and human samples through applications such as western blotting (WB) and immunofluorescence (IF). Anti-VPAC2 antibody (AS69) specifically targets VPAC2 receptor, which is a member of the G-protein coupled receptor family and plays a crucial role in mediating the effects of vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP). VPAC2 receptor is predominantly expressed in the brain and immune cells, where VPAC2 is involved in important physiological processes such as neuronal differentiation and T cell activation. VPAC2 receptor activates adenylyl cyclase, leading to increased levels of cyclic AMP, which is vital for various signaling pathways that regulate cellular responses. Additionally, VPAC2 receptor′s ability to interact with both VIP and PACAP highlights VPAC2′s significance in neuroendocrine signaling and potential implications in neurodevelopmental disorders and immune responses. VPAC2 monoclonal antibody (AS69) in detecting VPAC2 receptor makes this reagent an essential tool for researchers studying the intricate roles of peptide hormones in health and disease.
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VPAC2 Antibody (AS69) References:
- Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertension in rats. | Koga, M., et al. 2014. J Appl Physiol (1985). 117: 383-91. PMID: 24947028
- Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism. | Takeuchi, S., et al. 2020. Front Neurosci. 14: 521. PMID: 32581681
- The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit. | Patton, AP., et al. 2020. Nat Commun. 11: 3394. PMID: 32636383
- Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats. | Ulkumen, B., et al. 2022. Braz J Otorhinolaryngol. 88: 505-510. PMID: 32798199
- The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior. | Hamnett, R., et al. 2021. J Neurosci. 41: 502-512. PMID: 33234609
- Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes. | Hou, X., et al. 2022. Front Endocrinol (Lausanne). 13: 984198. PMID: 36204104
- VPAC1 and VPAC2 receptor deficiencies negatively influence pregnancy outcome through distinct and overlapping modulations of immune, trophoblast and vascular functions. | Calo, G., et al. 2023. Biochim Biophys Acta Mol Basis Dis. 1869: 166593. PMID: 36328148
- VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic β cells. | Zhao, X., et al. 2023. Exp Cell Res. 423: 113471. PMID: 36642263
- VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer. | Passang, T., et al. 2024. Cancer Res. 84: 2954-2967. PMID: 38809694
- VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model. | Guo, S., et al. 2024. J Headache Pain. 25: 126. PMID: 39085771
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VPAC2 Antibody (AS69) | sc-52795 | 50 µg/500 µl | $322.00 |