VP 14637 (CAS 235106-62-4)

VP 14637 is a chemical compound that has been explored in various scientific research contexts, particularly for its role in studying viral entry mechanisms. This compound is known for its specific interaction with viral components that are crucial for the early stages of viral infection. The primary focus of research on VP 14637 is its action as an entry inhibitor, which provides valuable insights into the prevention of viral propagation at a cellular level. The mechanism of action of VP 14637 involves the inhibition of the fusion between the viral envelope and the host cell membrane. It targets a specific protein or a set of proteins involved in the viral fusion machinery, which are essential for the virus to enter the host cell. By binding to these proteins, VP 14637 prevents the conformational changes required for the fusion of viral and cellular membranes, thereby blocking the virus from injecting its genetic material into the host cell. This action of VP 14637 has been particularly valuable in research focusing on viruses that use a well-defined fusion process to enter cells. Studies have used VP 14637 to better understand the specific steps and molecular interactions involved in viral entry. By inhibiting this process, researchers can dissect the sequence of events and identify potential targets for more effective inhibitors. Moreover, VP 14637 has been used in structural studies to explain the architecture of viral fusion proteins. By interacting with these proteins, VP 14637 helps stabilize them in a particular conformation that is amenable to analysis by techniques such as X-ray crystallography or cryo-electron microscopy. These studies provide a detailed view of the viral components at the atomic level, contributing to a deeper understanding of how viruses orchestrate entry into host cells.