Molecular structure of Voriconazole-d3, CAS Number: 188416-29-7
Voriconazole-d3 (CAS 188416-29-7)
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Alternate Names:
VRC-d3; Vfend-d3; Voriconazol-d3
CAS Number:
188416-29-7
Purity:
≥97% Isotopic Purity ≥99%
Molecular Weight:
352.33
Molecular Formula:
C16H11D3F3N5O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Voriconazole-d3 is a labeled form of Voriconazole, which is an Ergosterol biosynthesis inhibitor. Voriconazole inhibits fungal growth, cell wall thinning, and cell membrane degradation. The deuteration is intended to investigate the kinetics, metabolism, and molecular interactions of voriconazole. The incorporation of deuterium atoms allows researchers to track the metabolic pathway of voriconazole more accurately in biological systems. Such studies can provide insights into how voriconazole is processed, identifying metabolic intermediates and potential sites of metabolic instability.
Voriconazole-d3 (CAS 188416-29-7) References
- Bronchopulmonary disposition of intravenous voriconazole and anidulafungin given in combination to healthy adults. | Crandon, JL., et al. 2009. Antimicrob Agents Chemother. 53: 5102-7. PMID: 19770284
- Determination of Voriconazole Concentrations in Serum by GC-MS. | Smith, A. and Leung-Pineda, V. 2016. J Clin Lab Anal. 30: 411-7. PMID: 26351082
- Quantification of the Triazole Antifungal Compounds Voriconazole and Posaconazole in Human Serum or Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS). | Molinelli, AR. and Rose, CH. 2016. Methods Mol Biol. 1383: 39-47. PMID: 26660172
- A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum. | Basu, SS., et al. 2017. Clin Chem Lab Med. 55: 836-844. PMID: 27866173
- Oral absorption of voriconazole is affected by SLCO2B1 c.*396T>C genetic polymorphism in CYP2C19 poor metabolizers. | Lee, SW., et al. 2020. Pharmacogenomics J. 20: 792-800. PMID: 32461666
- Simultaneous Determination of Voriconazole and Its Voriconazole N-Oxide Metabolite in Human Urine by Liquid Chromatography/Tandem Mass Spectrometry. | Yu, Y., et al. 2022. J Chromatogr Sci. 60: 800-806. PMID: 34761250
- Assessment of greenness for the determination of voriconazole in reported analytical methods. | Chanduluru, HK. and Sugumaran, A. 2022. RSC Adv. 12: 6683-6703. PMID: 35424637
- Effects of Voriconazole Exposure on the Pharmacokinetics of Tacrolimus in Lung Transplantation Patients, Based on Therapeutic Drug Monitoring Data. | Chen, W., et al. 2022. J Clin Pharmacol. 62: 1310-1320. PMID: 35485761
- A UPLC-MS/MS method for simultaneous determination of eight special-grade antimicrobials in human plasma and application in TDM. | Qi, Y. and Liu, G. 2022. J Pharm Biomed Anal. 220: 114964. PMID: 36084471
- An LC-MS/MS method for the simultaneous determination of 18 antibacterial drugs in human plasma and its application in therapeutic drug monitoring. | Lu, W., et al. 2022. Front Pharmacol. 13: 1044234. PMID: 36425576
- Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species. | Belanger, P., et al. 1997. Antimicrob Agents Chemother. 41: 1840-2. PMID: 9257776
- In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens. | Espinel-Ingroff, A. 1998. J Clin Microbiol. 36: 198-202. PMID: 9431946
- In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp. | Marco, F., et al. 1998. Antimicrob Agents Chemother. 42: 161-3. PMID: 9449278
Inhibitor of:
CYP51A1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Voriconazole-d3, 1 mg | sc-220387 | 1 mg | $420.00 |