Date published: 2026-4-30

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VO-OHpic trihydrate (CAS 476310-60-8)

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Application:
VO-OHpic trihydrate is a PTEN inhibitor
CAS Number:
476310-60-8
Molecular Weight:
415.20
Molecular Formula:
C12H10N2O8V•3H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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VO-OHpic trihydrate, with its vanadium center coordinated to hydroxypicolinate ligands, is a focus of study for researchers interested in the fields of inorganic chemistry and catalysis. This compound is particularly noted for its ability to mimic the behavior of vanadium-dependent haloperoxidases, enzymes that are involved in the biosynthesis of various organic halogen compounds. By studying VO-OHpic trihydrate, chemists gain valuable insights into the potential for vanadium complexes to catalyze halogenation reactions, which are important in the synthesis of many organic molecules. In the realm of materials science, this compound is also investigated for its potential oxidative properties, which could be harnessed in the development of new catalysts for selective oxidation processes. Research involving this complex also extends to the study of metalloenzymes, contributing to a deeper understanding of metal ion transport and storage in biological systems.


VO-OHpic trihydrate (CAS 476310-60-8) References

  1. The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BON.  |  Silva, SR., et al. 2011. Anticancer Res. 31: 1153-60. PMID: 21508359
  2. mTor signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina.  |  Zelinka, CP., et al. 2016. Development. 143: 1859-73. PMID: 27068108
  3. MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway.  |  Zhang, Y., et al. 2018. Int J Mol Med. 41: 3699-3708. PMID: 29532889
  4. Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1α mediated signal pathway.  |  Wang, L., et al. 2018. Biochim Biophys Acta Gen Subj. 1862: 2281-2292. PMID: 30036603
  5. MiR-21 promotes pterygium cell proliferation through the PTEN/AKT pathway.  |  Li, X., et al. 2018. Mol Vis. 24: 485-494. PMID: 30967746
  6. Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1/PTEN/FAK signaling pathway in tongue cancer.  |  Li, JY., et al. 2019. BMC Cancer. 19: 391. PMID: 31023264
  7. miR‑29 promotes the proliferation of cultured rat neural stem/progenitor cells via the PTEN/AKT signaling pathway.  |  Gao, Y., et al. 2019. Mol Med Rep. 20: 2111-2118. PMID: 31257508
  8. PTEN/AKT/mTOR signaling mediates anticancer effects of epigallocatechin‑3‑gallate in ovarian cancer.  |  Qin, J., et al. 2020. Oncol Rep. 43: 1885-1896. PMID: 32236585
  9. Activation of Type 4 Metabotropic Glutamate Receptor Regulates Proliferation and Neuronal Differentiation in a Cultured Rat Retinal Progenitor Cell Through the Suppression of the cAMP/PTEN/AKT Pathway.  |  Zhang, Z., et al. 2020. Front Mol Neurosci. 13: 141. PMID: 32973444
  10. MiRNA-132 regulates the development of osteoarthritis in correlation with the modulation of PTEN/PI3K/AKT signaling.  |  Zhang, W., et al. 2021. BMC Geriatr. 21: 175. PMID: 33691628
  11. MicroRNA-1297 suppressed the Akt/GSK3β signaling pathway and stimulated neural apoptosis in an in vivo sevoflurane exposure model.  |  Wang, Q., et al. 2021. J Int Med Res. 49: 300060520982104. PMID: 33843359
  12. PTEN regulates proliferation and osteogenesis of dental pulp cells and adipogenesis of human adipose-derived stem cells.  |  Nowwarote, N., et al. 2023. Oral Dis. 29: 735-746. PMID: 34558757
  13. Mycobacterium tuberculosis ESAT6 modulates host innate immunity by downregulating miR-222-3p target PTEN.  |  Zonghai, C., et al. 2022. Biochim Biophys Acta Mol Basis Dis. 1868: 166292. PMID: 34710568

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

VO-OHpic trihydrate, 10 mg

sc-216061
10 mg
$179.00

VO-OHpic trihydrate, 25 mg

sc-216061A
25 mg
$398.00