Molecular structure of VK-28, CAS Number: 312611-92-0
VK-28 (CAS 312611-92-0)
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Alternate Names:
5-[[4-(2-Hydroxyethyl)-1-piperazinyl]methyl]-8-quinolinol
CAS Number:
312611-92-0
Purity:
≥98%
Molecular Weight:
287.36
Molecular Formula:
C16H21N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
VK-28 is a neuroprotectant compound and a brain permeable iron chelator. It is designed to act as a metal chelator, meaning it has the ability to bind to metal ions such as iron and copper. By binding to these metals, VK-28 may help to prevent or reduce their harmful effects. Studies have shown that VK-28 has antioxidant properties, which means it can help neutralize harmful free radicals and reduce oxidative stress in cells. Furthermore, VK-28 has been utilized in scientific research for its potential to promote the clearance of toxic protein aggregates, such as beta-amyloid plaques in Alzheimer′s disease and alpha-synuclein in Parkinson′s disease. By enhancing protein clearance mechanisms, VK-28 may help to reduce the buildup of these toxic proteins in the brain.
VK-28 (CAS 312611-92-0) References
- What have we learnt from CDNA microarray gene expression studies about the role of iron in MPTP induced neurodegeneration and Parkinson's disease? | Youdim, MB. 2003. J Neural Transm Suppl. 73-88. PMID: 12946050
- Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. | Shachar, DB., et al. 2004. Neuropharmacology. 46: 254-63. PMID: 14680763
- Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28. | Youdim, MB., et al. 2004. Ann N Y Acad Sci. 1012: 306-25. PMID: 15105275
- Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion. | Gal, S., et al. 2005. J Neurochem. 95: 79-88. PMID: 16181414
- Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders. | Mandel, S., et al. 2006. Mol Nutr Food Res. 50: 229-34. PMID: 16470637
- M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease. | Gal, S., et al. 2006. J Neural Transm Suppl. 447-56. PMID: 17017567
- Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator. | Bandyopadhyay, S., et al. 2006. J Neural Transm Suppl. 237-47. PMID: 17447434
- Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators. | Zhu, W., et al. 2007. FASEB J. 21: 3835-44. PMID: 17690154
- Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG. | Avramovich-Tirosh, Y., et al. 2007. Curr Alzheimer Res. 4: 403-11. PMID: 17908043
- Iron-induced oxidative stress modulates olfactory learning and memory in honeybees. | Farooqui, T. 2008. Behav Neurosci. 122: 433-47. PMID: 18410182
- Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis. | Wang, Q., et al. 2011. Neurodegener Dis. 8: 310-21. PMID: 21346313
- Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice. | Li, Q., et al. 2017. J Cereb Blood Flow Metab. 37: 3110-3123. PMID: 28534662
- Exploring the Multifunctional Neuroprotective Promise of Rasagiline Derivatives for Multi-Dysfunctional Alzheimer's Disease. | Uddin, MS., et al. 2020. Curr Pharm Des. 26: 4690-4698. PMID: 32250219
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VK-28, 10 mg | sc-253831 | 10 mg | $275.00 |