Vitronectin 75 Antibody (A18): sc-80558
- Vitronectin 75 Antibody (A18) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against lysed corneal endothelial cells and extracellular matrix of bovine origin
- recommended for detection of Vitronectin 75 of bovine and equine origin by IF; non cross-reactive with other connective tissue proteins (Fibronectin, Elastin, Collagen, Laminin)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Vitronectin 75 Antibody (A18). This work is in progress.
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Vitronectin 75 Antibody (A18) is a mouse monoclonal IgG1 antibody that detects Vitronectin in bovine and equine species through immunofluorescence (IF) applications. Vitronectin is a crucial extracellular matrix glycoprotein that plays a significant role in cell adhesion, motility, and wound healing, making Vitronectin essential for tissue repair and regeneration. Vitronectin is primarily located in the extracellular matrix and plasma, where Vitronectin interacts with various cell types to facilitate adhesion and migration. The presence of the RGD (Arg-Gly-Asp) sequence within Vitronectin is particularly important, as this sequence is a key motif recognized by integrins, which are vital for cell attachment to the extracellular matrix. Increased expression of Vitronectin has been observed in migrating cells during wound healing, highlighting Vitronectin′s role in promoting smooth muscle cell migration. Additionally, Vitronectin′s interaction with plasminogen activators and binding affinity to PAI-1 (Plasminogen Activator Inhibitor-1) can influence cell migration dynamics, as PAI-1 can inhibit this process when bound to Vitronectin. Understanding Vitronectin′s function and interactions is critical for elucidating Vitronectin′s role in various physiological and pathological processes, including tissue repair and cancer metastasis.
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Vitronectin 75 Antibody (A18) References:
- Vitronectin is implicated as the matrix takes control of neointima formation. | Newby, AC. 2002. Cardiovasc Res. 53: 779-81. PMID: 11922889
- Vitronectin in human breast carcinomas. | Aaboe, M., et al. 2003. Biochim Biophys Acta. 1638: 72-82. PMID: 12757937
- Structure and biological role of vitronectin. | Preissner, KT. 1991. Annu Rev Cell Biol. 7: 275-310. PMID: 1725600
- Vitronectin in bacterial pathogenesis: a host protein used in complement escape and cellular invasion. | Singh, B., et al. 2010. Mol Microbiol. 78: 545-60. PMID: 20807208
- Interaction of vitronectin with collagen. | Gebb, C., et al. 1986. J Biol Chem. 261: 16698-703. PMID: 2430969
- Serum osteopontin and vitronectin levels in systemic sclerosis. | Gundogdu, B., et al. 2017. Adv Clin Exp Med. 26: 1231-1236. PMID: 29264880
- Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma. | Burgos-Panadero, R., et al. 2019. BMC Cancer. 19: 479. PMID: 31117974
- A vitronectin-derived dimeric peptide suppresses osteoclastogenesis by binding to c-Fms and inhibiting M-CSF signaling. | Jung, SY. and Min, BM. 2022. Exp Cell Res. 418: 113252. PMID: 35697077
- Calcium-induced environmental adaptability of the blood protein vitronectin. | Tian, Y., et al. 2022. Biophys J. 121: 3896-3906. PMID: 36056555
- Recruitment of Vitronectin by Bacterial Pathogens: A Comprehensive Overview. | Pellegrini, A. and Pietrocola, G. 2024. Microorganisms. 12: PMID: 39065153
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vitronectin 75 Antibody (A18) | sc-80558 | 100 µg/ml | $322.00 |