Visual Arrestin Antibody (C-1): sc-271159

Visual Arrestin Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Visual Arrestin, also known as Arrestin 1, retinal S-antigen, or S-Arrestin, in multiple species including human, mouse, rat, equine, canine, and bovine. Anti-Visual Arrestin antibody (C-1) is raised against a peptide within an internal region of the human Visual Arrestin protein, enabling reliable detection in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Visual Arrestin plays a crucial role in the phototransduction pathway by binding to phosphorylated rhodopsin, thereby terminating the light signal and preventing continuous activation of G protein-coupled receptors. Additionally, Visual Arrestin interacts with G protein-coupled receptor kinases (GRKs) to facilitate receptor desensitization and promote receptor internalization through clathrin-mediated endocytosis. These interactions are essential for maintaining precise control over visual signal transduction, ensuring accurate visual perception and preventing signal desensitization. Visual Arrestin is predominantly localized in the outer segments of retinal photoreceptor cells and the pineal gland, where Visual Arrestin contributes to the regulation of circadian rhythms. The strategic cellular localization and interaction with key proteins like rhodopsin and GRKs highlight Visual Arrestin′s importance in both vision and overall physiological regulation. Furthermore, Visual Arrestin serves as a major pathogenic autoantigen in inflammatory eye diseases such as uveoretinitis and Oguchi disease, a rare form of night blindness, underscoring Visual Arrestin′s significance in ocular health and disease. Visual Arrestin (C-1) antibody facilitates comprehensive studies of this protein′s function and interactions, supporting research into visual signal transduction, retinal disorders, and autoimmune conditions.

The preferred β-Arrestin-2 antibody is β-Arrestin-2 Antibody (H-9): sc-13140.