Molecular structure of Virstatin, CAS Number: 88909-96-0
Virstatin (CAS 88909-96-0)
See product citations (2)
Alternate Names:
4-(N-(1,8-Naphthalimide))-n-butyric acid
Application:
Virstatin is a ToxT inhibitor
CAS Number:
88909-96-0
Molecular Weight:
283.28
Molecular Formula:
C16H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Virstatin inhibits virulence regulation in V. cholerae. Virstatin prevents expression of cholera toxin and the toxin coregulated pilus (TCP) by inhibiting the transcriptional regulator ToxT. Virstatin may act to have a direct antiviral effect by preventing the virus from entering the cell and replicating.
Virstatin (CAS 88909-96-0) References
- Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. | Hung, DT., et al. 2005. Science. 310: 670-4. PMID: 16223984
- Virstatin inhibits dimerization of the transcriptional activator ToxT. | Shakhnovich, EA., et al. 2007. Proc Natl Acad Sci U S A. 104: 2372-7. PMID: 17283330
- Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae. | Shakhnovich, EA., et al. 2007. Mol Microbiol. 66: 1331-41. PMID: 17986190
- Accessory cholera enterotoxin, Ace, from Vibrio cholerae: structure, unfolding, and virstatin binding. | Chatterjee, T., et al. 2011. Biochemistry. 50: 2962-72. PMID: 21366345
- N-terminal residues of the Vibrio cholerae virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids. | Childers, BM., et al. 2011. J Biol Chem. 286: 28644-55. PMID: 21673111
- Interaction of virstatin with human serum albumin: spectroscopic analysis and molecular modeling. | Chatterjee, T., et al. 2012. PLoS One. 7: e37468. PMID: 22649528
- Virstatin inhibits biofilm formation and motility of Acinetobacter baumannii. | Nait Chabane, Y., et al. 2014. BMC Microbiol. 14: 62. PMID: 24621315
- Mechanism for inhibition of Vibrio cholerae ToxT activity by the unsaturated fatty acid components of bile. | Plecha, SC. and Withey, JH. 2015. J Bacteriol. 197: 1716-25. PMID: 25733618
- Role of LuxIR Homologue AnoIR in Acinetobacter nosocomialis and the Effect of Virstatin on the Expression of anoR Gene. | Oh, MH. and Choi, CH. 2015. J Microbiol Biotechnol. 25: 1390-400. PMID: 25975610
- Pathophysiological mechanisms of diarrhea caused by the Vibrio cholerae O1 El Tor variant: an in vivo study in mice. | Satitsri, S., et al. 2016. Virulence. 7: 789-805. PMID: 27222028
- Design of an anti-adhesive surface by a pilicide strategy. | Reffuveille, F., et al. 2016. Colloids Surf B Biointerfaces. 146: 895-901. PMID: 27469573
- 3-Amino 1,8-naphthalimide, a structural analog of the anti-cholera drug virstatin inhibits chemically-biased swimming and swarming motility in vibrios. | Wang, H., et al. 2017. Microbes Infect. 19: 370-375. PMID: 28392408
- Unsaturated Fatty Acids Affect Quorum Sensing Communication System and Inhibit Motility and Biofilm Formation of Acinetobacter baumannii. | Nicol, M., et al. 2018. Int J Mol Sci. 19: PMID: 29320462
- Virstatin-Conjugated Gold Nanoparticle with Enhanced Antimicrobial Activity against the Vibrio cholerae El Tor Biotype. | Jana, SK., et al. 2021. ACS Appl Bio Mater. 4: 3089-3100. PMID: 35014397
Inhibitor of:
Bordetella.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Virstatin, 10 mg | sc-358715 | 10 mg | $45.00 | |||
Virstatin, 50 mg | sc-358715A | 50 mg | $182.00 |