Molecular structure of Virginiamycin Complex, CAS Number: 11006-76-1
Virginiamycin Complex (CAS 11006-76-1)
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Alternate Names:
Virginiamycin Complex is also known as Mikamycin.
Application:
Virginiamycin Complex is a mixture of two streptogramin antibiotics, Virginiamycins M1 and S1, that act synergistically to inhibit protein synthesis in bacteria.
CAS Number:
11006-76-1
Purity:
99%
Molecular Weight:
525.6 (Virginiamycin M1) & 823.9 (Virginiamycin S1)
Molecular Formula:
C28H35N3O7 (Virginiamycin M1) & C43H49N7O10 (Virginiamycin S1)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Virginiamycin Complex is a solid powder mixture of 75% virginiamycin M1 (Ostreogrycin A, sc-202269) and 25% virginiamycin S1(sc-202384), two streptogramin antibiotics which present a synergistic bacteriocidal action. Virginiamycin M1 inhibits the function of the 50S ribosomal subunit without blocking its assembly, producing a bacteriostatic effect. With the addition of the virginiamycin S1 component, the Virginiamycin Complex presents bacteriocidal effects, indicating an interaction between the two compounds upon their association with the ribosome. Virginiamycin Complex, when given to livestock, may improve growth. Virginiamycin Complex can control bacteria competing with yeast in fuel ethanol fermenters.
Virginiamycin Complex (CAS 11006-76-1) References
- Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. | Champney, WS. and Tober, CL. 2000. Curr Microbiol. 41: 126-35. PMID: 10856379
- In search of natural substrates and inhibitors of MDR pumps. | Lewis, K. 2001. J Mol Microbiol Biotechnol. 3: 247-54. PMID: 11321580
- Pesticidal activity of virginiamycins S1 and M1. | Prikrylová, V., et al. 1992. Folia Microbiol (Praha). 37: 386-8. PMID: 1493906
- Taxonomic studies of Streptomyces virginiae mutants overproducing virginiamycin M1. | Rezanka, T., et al. 1992. Folia Microbiol (Praha). 37: 105-10. PMID: 1505866
- Use of 50 S-binding antibiotics to characterize the ribosomal site to which peptidyl-tRNA is bound. | Odom, OW. and Hardesty, B. 1992. J Biol Chem. 267: 19117-22. PMID: 1527036
- Phenotypic and genotypic characterization of mutants of the virginiamycin producing strain 899 and its relatedness to the type strain of Streptomyces virginiae. | Lanoot, B., et al. 2005. Syst Appl Microbiol. 28: 77-84. PMID: 15709368
- Effects of low concentrations of erythromycin, penicillin, and virginiamycin on bacterial resistance development in vitro. | Ge, B., et al. 2017. Sci Rep. 7: 11017. PMID: 28887450
- Molecular mechanism of action of virginiamycin-like antibiotics (synergimycins) on protein synthesis in bacterial cell-free systems. | Cocito, C. and Chinali, G. 1985. J Antimicrob Chemother. 16 Suppl A: 35-52. PMID: 3932310
- Lasting damage to bacterial ribosomes by reversibly bound virginiamycin M. | Parfait, R. and Cocito, C. 1980. Proc Natl Acad Sci U S A. 77: 5492-6. PMID: 6776538
- Chemical probing of a virginiamycin M-promoted conformational change of the peptidyl-transferase domain. | Vannuffel, P., et al. 1994. Nucleic Acids Res. 22: 4449-53. PMID: 7971275
- Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms. | Porse, BT. and Garrett, RA. 1999. J Mol Biol. 286: 375-87. PMID: 9973558
- Strain Development in Streptomyces virginiae, a Producer of Virginiamycyn | Prikrylova, V., Blumauerova, M., Sedmera, P., Vanek, Z., Marsalek, J., & Kristan, V. 1987. Biotechnology & Bioindustry. 2(2): 20-22.
- High-performance liquid chromatographic determination of virginiamycin in Stafac, premixes and animal feeds | Gossele, F., Blain, P., Marneffe, T., & Biot, A. 1991. Analyst. 116(12): 1373-1380.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Virginiamycin Complex, 5 mg | sc-202383 | 5 mg | $362.00 |