Molecular structure of Vincamine, CAS Number: 1617-90-9
Vincamine (CAS 1617-90-9)
Application:
Vincamine is a peripheral vasodilator
CAS Number:
1617-90-9
Purity:
≥98%
Molecular Weight:
354.44
Molecular Formula:
C21H26N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Vincamine is a chemical compound that functions as a peripheral vasodilator. It acts by inhibiting the reuptake of serotonin and norepinephrine, leading to increased levels of these neurotransmitters in the brain. This mechanism of action results in improved blood flow to the brain and enhanced oxygen and glucose utilization by brain cells. Vincamine also has the ability to modulate calcium channels, which further contributes to its vasodilatory effects. Vincamine interacts with specific receptors and transporters in the brain, ultimately leading to its functional role as a vasodilator. Vincamine′s mechanism of action is of interest in various experiments where the modulation of neurotransmitter levels and calcium channels is relevant.
Vincamine (CAS 1617-90-9) References
- Vincamine-producing endophytic fungus isolated from Vinca minor. | Yin, H. and Sun, YH. 2011. Phytomedicine. 18: 802-5. PMID: 21315568
- Vincamine Alleviates Amyloid-β 25-35 Peptides-induced Cytotoxicity in PC12 Cells. | Han, J., et al. 2017. Pharmacogn Mag. 13: 123-128. PMID: 28216895
- An update on vinpocetine: New discoveries and clinical implications. | Zhang, YS., et al. 2018. Eur J Pharmacol. 819: 30-34. PMID: 29183836
- Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice. | Du, T., et al. 2019. J Endocrinol. 240: 195-214. PMID: 30400036
- Improvement of vincamine production of endophytic fungus through inactivated protoplast fusion. | Xu, S., et al. 2020. Int Microbiol. 23: 441-451. PMID: 31927642
- Efficacy of Vincamine treatment in a rat model of anterior ischemic optic neuropathy. | Li, L., et al. 2021. Eur J Ophthalmol. 31: 3442-3449. PMID: 33222520
- Vincamine, a safe natural alkaloid, represents a novel anticancer agent. | Al-Rashed, S., et al. 2021. Bioorg Chem. 107: 104626. PMID: 33450545
- Vincamine protects against cisplatin induced nephrotoxicity via activation of Nrf2/HO-1 and hindering TLR4/ IFN-γ/CD44 cells inflammatory cascade. | El-Sayed, RM., et al. 2021. Life Sci. 272: 119224. PMID: 33610575
- Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways. | Fawzy, MA., et al. 2022. Molecules. 27: PMID: 35209172
- Vincamine, an active constituent of Vinca rosea ameliorates experimentally induced acute lung injury in Swiss albino mice through modulation of Nrf-2/NF-κB signaling cascade. | Patangrao Renushe, A., et al. 2022. Int Immunopharmacol. 108: 108773. PMID: 35453074
- Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. | Dhyani, P., et al. 2022. Cancer Cell Int. 22: 206. PMID: 35655306
- Vobasine, vincamine, voaphylline, tacaman, and iboga alkaloids from Tabernaemontana corymbosa. | Sim, DS., et al. 2022. Phytochemistry. 203: 113384. PMID: 36007666
- Evaluation of vincamine against Acetylcholinesterase enzyme. | Syed Sayeed Ahmad, ., et al. 2022. Cell Mol Biol (Noisy-le-grand). 68: 14-21. PMID: 36495525
- Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats. | Parlar Köprülü, RE., et al. 2022. Iran J Pharm Res. 21: e132265. PMID: 36942057
- Pharmacokinetics and metabolism of vincamine and related compounds. | Vereczkey, L. 1985. Eur J Drug Metab Pharmacokinet. 10: 89-103. PMID: 3899662
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vincamine, 1 g | sc-224365 | 1 g | $131.00 |