Molecular structure of Vinblastine Sulfate, CAS Number: 143-67-9
Vinblastine Sulfate (CAS 143-67-9)
See product citations (9)
Alternate Names:
VLB; Vincaleukoblastine sulfate salt
Application:
Vinblastine Sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase
CAS Number:
143-67-9
Purity:
≥98%
Molecular Weight:
909.05
Molecular Formula:
C46H58N4O9•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Vinblastine Sulfate is an antineoplastic agent with anti-mitotic properties and immunosuppressive activity. Vinblastine sulfate depolymerizes microtubules by binding tubulin and inducing self-association in spiral aggregates. This reaction that appears to be regulated by the C-terminus of beta-Tubulin and is enhanced by GDP and GTP. Vinblastine sulfate has been observed to arrest the cell cycle in the G2/M-phase by blocking mitotic spindle formation. Vinblastine sulfate has also been documented to trigger Raf-1 activation and phosphorylation of Bcl-2 family proteins, to induce p53 expression, and to induce apoptosis in several tumor cell lines. The compound has also acted as a substrate of PGP and CYP3A4.
Vinblastine Sulfate (CAS 143-67-9) References
- MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells. | Chen, GK., et al. 2000. Br J Cancer. 83: 892-8. PMID: 10970691
- Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules. | Himes, RH. 1991. Pharmacol Ther. 51: 257-67. PMID: 1784631
- Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. | Luo, L., et al. 2007. AAPS J. 9: E329-35. PMID: 18170979
- A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis. | Chu, C., et al. 2022. J Chromatogr A. 1664: 462794. PMID: 34998026
- Chitosan-Hyaluronan Nanoparticles for Vinblastine Sulfate Delivery: Characterization and Internalization Studies on K-562 Cells. | Cannavà, C., et al. 2022. Pharmaceutics. 14: PMID: 35631528
- Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. | Jordan, MA., et al. 1985. Cancer Res. 45: 2741-7. PMID: 3986806
- Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. | Tsukidate, K., et al. 1993. Am J Pathol. 143: 918-25. PMID: 8362985
- Differential effects of vinblastine on polymerization and dynamics at opposite microtubule ends. | Panda, D., et al. 1996. J Biol Chem. 271: 29807-12. PMID: 8939919
- The C terminus of beta-tubulin regulates vinblastine-induced tubulin polymerization. | Rai, SS. and Wolff, J. 1998. Proc Natl Acad Sci U S A. 95: 4253-7. PMID: 9539723
- Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. | Jordan, A., et al. 1998. Med Res Rev. 18: 259-96. PMID: 9664292
- Use of drugs to study role of microtubule assembly dynamics in living cells. | Jordan, MA. and Wilson, L. 1998. Methods Enzymol. 298: 252-76. PMID: 9751887
- Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubule assembly. | Rai, SS. and Wolff, J. 1998. J Biol Chem. 273: 31131-7. PMID: 9813016
- Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells. | Tashiro, E., et al. 1998. Jpn J Cancer Res. 89: 940-6. PMID: 9818030
Inhibitor of:
α4a Tubulin, AP1S2_Ap1s2, AP1S3, ARL11, BC006779, CapG, CD155 (PVR; polio virus receptor), DNAH17, LOC643909, Mad 4, NF-L, Rec8, SSNA1, ST7, Tektin 4, Tubulin, and WDR55.Activator of:
BBS8, Coronin 1C, CP110, DNAL1, GCP3, IFT88, KAP3, LIPN, LIR-8, MRCKβ, NEDD1, NKHC2, NTF2, NUDC, Pericentrin 1, Rab11-FIP5, Sec6, Septin 5, SNX4, SPAG5, SUN2, TPX2, and TTBK1.Substrate of:
CYP3A4, and PGP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vinblastine Sulfate, 10 mg | sc-201447 | 10 mg | $107.00 | |||
Vinblastine Sulfate, 50 mg | sc-201447A | 50 mg | $404.00 | |||
Vinblastine Sulfate, 100 mg | sc-201447B | 100 mg | $550.00 | |||
Vinblastine Sulfate, 1 g | sc-201447C | 1 g | $2200.00 |