Date published: 2025-10-2

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Vinblastine (CAS 865-21-4)

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Application:
Vinblastine is inhibits microtubule formation and suppresses nAChR activity
CAS Number:
865-21-4
Molecular Weight:
810.97
Molecular Formula:
C46H58N4O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Vinblastine, an analogue of vincristine, acts by binding to tubulin and impeding the assembly of microtubules. This disruption of microtubule formation and proper organization of the mitotic spindle and kinetochore leads to cell cycle arrest specifically in the M phase. As a result, chromosome separation during anaphase of mitosis is hindered. Additionally, vinblastine inhibits microtubule formation and suppresses nAChR (nicotinic acetylcholine receptor) activity.


Vinblastine (CAS 865-21-4) References

  1. Vinblastine perturbation of tubulin protofilament structure: a computational insight.  |  Rendine, S., et al. 2010. Phys Chem Chem Phys. 12: 15530-6. PMID: 20978652
  2. Determination of vinblastine in tumour tissue with liquid chromatography-high resolution mass spectrometry.  |  Kosjek, T., et al. 2013. Talanta. 116: 887-93. PMID: 24148490
  3. Reaction phenotyping of vinblastine metabolism in dogs.  |  Achanta, S. and Maxwell, LK. 2016. Vet Comp Oncol. 14: 161-9. PMID: 24502418
  4. Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.  |  Allemann, O., et al. 2016. J Am Chem Soc. 138: 8376-9. PMID: 27356080
  5. Fluorescent vinblastine probes for live cell imaging.  |  Meimetis, LG., et al. 2016. Chem Commun (Camb). 52: 9953-6. PMID: 27439765
  6. Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas.  |  Kipper, FC., et al. 2018. Invest New Drugs. 36: 323-331. PMID: 28852916
  7. Vinblastine-induced posterior reversible encephalopathy syndrome.  |  Ayesh Haj Yousef, MH., et al. 2019. J Oncol Pharm Pract. 25: 2019-2022. PMID: 30537916
  8. Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound.  |  Radakovic, A. and Boger, DL. 2019. Bioorg Med Chem Lett. 29: 1370-1374. PMID: 30952593
  9. Vinblastine production by the endophytic fungus Curvularia verruculosa from the leaves of Catharanthus roseus and its in vitro cytotoxicity against HeLa cell line.  |  Parthasarathy, R., et al. 2020. Anal Biochem. 593: 113530. PMID: 31794703
  10. Discovery of the anticancer drug vinblastine from the endophytic Alternaria alternata and yield improvement by gamma irradiation mutagenesis.  |  El-Sayed, ER. 2021. J Appl Microbiol. 131: 2886-2898. PMID: 34062037
  11. Combination vinblastine and palladia for high-grade and metastatic mast cell tumors in dogs.  |  Todd, JE., et al. 2021. Can Vet J. 62: 1335-1340. PMID: 34857971
  12. A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS.  |  van der Heijden, LT., et al. 2022. J Pharm Biomed Anal. 215: 114772. PMID: 35462284
  13. Thermodynamic and structural profiles of multi-target binding of vinblastine in solution.  |  Gopi, P., et al. 2022. J Mol Recognit. 35: e2989. PMID: 36054496
  14. Genotoxicity, DNA damage and sperm defects induced by vinblastine.  |  Fahmy, MA., et al. 2023. Mol Biol Rep. 50: 1059-1068. PMID: 36394708
  15. CCNB1 and AURKA are critical genes for prostate cancer progression and castration-resistant prostate cancer resistant to vinblastine.  |  Chen, X., et al. 2022. Front Endocrinol (Lausanne). 13: 1106175. PMID: 36601001

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Vinblastine, 10 mg

sc-491749
10 mg
$100.00

Vinblastine, 50 mg

sc-491749A
50 mg
$230.00

Vinblastine, 100 mg

sc-491749B
100 mg
$450.00

Vinblastine, 500 mg

sc-491749C
500 mg
$1715.00

Vinblastine, 1 g

sc-491749D
1 g
$2900.00