Vildagliptin CAS: 274901-16-5
MF: C17H25N3O2
MW: 303.40
A CD26 inhibitor associated with immune response inhibition.

Vildagliptin (CAS 274901-16-5)

Vildagliptin | CAS 274901-16-5 is rated 5.0 out of 5 by 1.
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Synonym: LAF237
Application: A CD26 inhibitor associated with immune response inhibition
CAS Number: 274901-16-5
Purity: ≥97%
Molecular Weight: 303.40
Molecular Formula: C17H25N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor. CD26 activates serine proteases in immune/inflammatory cells. Vildagliptin also inhibits dipeptidyl-peptidase 8 (DPRP1) and dipeptidyl-peptidase 9 (DPRP2), which have been correlated to T cell activation and immune function, as well as diabetes and cancer regulation.


References

1. Ahrén, B. et al. 2004. J. Clin. Endocrinol. Metab. 89(5): 2078-2084. PMID: 15126524

2. Ahrén, B. et al. 2004. Diabetes Care. 27(12): 2874-2880. PMID: 15562200

3. Barlocco, D. 2004. Curr Opin Investig Drugs. 5(10): 1094-1100. PMID: 15535431

Physical State :
Solid
Solubility :
Soluble in DMSO and Water
Storage :
Store at -20° C
Melting Point :
153-155
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918537
SMILES :
C1C[[email protected]](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N

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Certificate of Analysis

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Vildagliptin  Product Citations

See how others have used Vildagliptin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25297967  Kawaguchi, T. et al. 2014. Hepatol. Res.

Citations 1 to 1 of 1 total

What is the stability of the powder at -20°C ?

Asked by: CélineV
Thank you for your question. We provide a warranty of one year on the viability of our products given proper storage conditions. To find out the lot-specific expiry date please contact our technical service providing the lot number of your purchased product.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29
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Rated 5 out of 5 by from Khan et al Khan et al. (PubMed ID 263575866) found that vidagliptin influenced biomarkers linked with the progression of thrombosis and might be able to delay thrombogenesis linked to diabetes mellitus. -SCBT Publication Review
Date published: 2015-02-15
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