Molecular structure of Vicriviroc Malate, CAS Number: 541503-81-5
Vicriviroc Malate (CAS 541503-81-5)
Application:
Vicriviroc Malate is a potent CCR5 antagonist with IC50 of 0.91 nM
CAS Number:
541503-81-5
Molecular Weight:
667.72
Molecular Formula:
C28H38F3N5O2•C4H6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Vicriviroc Malate is a potent CKR-5 (CCR5) antagonist with IC50 of 0.91 nM. It has a higher binding affinity to CCR5 as opposed to SCH-C in competition binding assays. Vicriviroc Malate is close to 6-fold less active than SCH-C in attenuating hERG current among In voltage-clamped L929 cells. It inhibits GTPγS binding to the membranes from HTS-hCCR5 cells induced by RANTES. Vicriviroc Malate also displays potent antiviral activity against a panel of 30 R5-tropic HIV-1 isolates. It possibly targets an early step in the viral life cycle prior to reverse transcription and virion maturation.
Vicriviroc Malate (CAS 541503-81-5) References
- Altered T Cell Migratory Capacity in the Progression from Barrett Oesophagus to Oesophageal Adenocarcinoma. | Kavanagh, ME., et al. 2019. Cancer Microenviron. 12: 57-66. PMID: 30834503
Inhibitor of:
CKR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vicriviroc Malate, 5 mg | sc-364644 | 5 mg | $192.00 | |||
Vicriviroc Malate, 50 mg | sc-364644A | 50 mg | $1341.00 |