Verapamil hydrochloride (CAS 152-11-4)

物理状态 :

Solid

溶解度 :

Soluble in water (83 mg/mL), ethanol (200 proof) (26 mg/mL), methanol (>100 mg/mL), propylene glycol (93 mg/mL), ethanol (190 proof) (>100 mg/mL), 2-propanol (4.6 mg/mL), ethyl acetate (1.0 mg/mL), DMF (>100 mg/mL), dichloromethane (>100 mg/mL), chloroform (sparingly at 21° C), and hexane (0.001 mg/mL).

保存 :

Store at room temperature

熔点 :

~142° C (dec.)

折射率 :

n²⁵_D 1.54

IC50 :

Intracellular uptake of drug in presence of 3H VBL and VRP: IC₅₀ = 23 nM ( 2SC/20 cell line); Intracellular uptake of drug in presence of 3H VBL and VRP: IC₅₀ = 29 nM (HET-SR-2SC-LNM cell line); Intracellular uptake of drug in presence of 3H VBL and absence of VRP: IC₅₀ = 22 nM (HET-SR-2SC-LNM cell line); Intracellular uptake of drug in presence of 3H VBL and in absence of VRP: IC₅₀ = 10 nM (2SC/20 cell line); T.Cruzi Infection: EC₅₀50 = 61 nM; T.Cruzi Replication.: EC₅₀50 = 100 nM

pK值 :

pK_a: 8.92, pK_b: 8.97

德国水公害等级 :

3

RTECS :

YV8320000

PubChem CID :

Merck 索引 :

14: 9950

MDL 号码 :

MFCD00055208

EC号码 :

205-800-5

Beilstein 注册 :

3647093

SMILES :

CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl